Reactome | CASK [cytosol]

CASK [cytosol]

Stable Identifier

R-HSA-373631

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Peripheral plasma membrane protein CASK

Locations in the PathwayBrowser for interactor UniProt:P25054 APC

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External Reference Information

External Reference

UniProt:O14936 CASK

Gene Names

CASK, LIN2

Chain

chain:1-926

Reference Genes

BioGPS Gene:8573 CASK

COSMIC - genes:CASK CASK

CTD Gene:8573 CASK

dbSNP Gene:8573 CASK

ENSEMBL:ENSG00000147044 CASK

HGNC:1497 CASK

KEGG:hsa:8573 CASK

Monarch:8573 CASK

NCBI Gene:8573 CASK

OMIM:300172 CASK

UCSC:O14936 CASK

Reference Transcript

Participates

as a component of

as an input of

Inferred To

cask [cytosol] (Xenopus tropicalis)

lin-2 [cytosol] (Caenorhabditis elegans)

CASK [cytosol] (Bos taurus)

CASK [cytosol] (Canis familiaris)

CASK [cytosol] (Drosophila melanogaster)

CASK [cytosol] (Gallus gallus)

CASK [cytosol] (Rattus norvegicus)

CASK [cytosol] (Sus scrofa)

caskb [cytosol] (Danio rerio)

Cask [cytosol] (Mus musculus)

Cross References

RefSeq

NP_001119526.1, NP_003679.2, NP_001119527.1, NP_001354650.1

ZINC - World Drugs

CSKP_HUMAN

Guide to Pharmacology - Targets

1959

OpenTargets

ENSG00000147044

ENSEMBL

ENSP00000367405, ENST00000645566, ENST00000644347, ENSP00000494183, ENSG00000147044, ENSP00000495291, ENSP00000494788, ENSP00000367396, ENST00000378154, ENST00000378163, ENST00000646120

ZINC - FDA approved

CSKP_HUMAN

ZINC - Substances

CSKP_HUMAN

ZINC - Biogenic

CSKP_HUMAN

ZINC target

O14936

PRO

O14936

GlyGen

O14936

PDB

1KGD, 3MFS, 6KMH, 3MFU, 3MFR, 3C0I, 3C0G, 3TAC, 7OAI, 7OAK, 7OAL, 7OAJ, 1ZL8, 3MFT, 1KWA, 3C0H

ZINC - Investigational

CSKP_HUMAN

GeneCards

CASK

HPA

ENSG00000147044-CASK

Pharos - Targets

O14936

Orphanet

CASK

ZINC - Predictions - Purchasable

CSKP_HUMAN

HMDB Protein

HMDBP08709

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14910 LIN7A	2	LIN7A [plasma membrane] (R-HSA-5216076) LIN7A [transport vesicle membrane] (R-HSA-9610413)	0.825	7
UniProt:Q13009 TIAM1	3	TIAM1 [cytosol] (R-HSA-195013) p-Y-TIAM1 [cytosol] (R-HSA-9970162) p-Y829-TIAM1 [cytosol] (R-HSA-3928461)	0.772	4
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.713	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.706	5
UniProt:Q02410 APBA1	1	APBA1 [cytosol] (R-HSA-5336459)	0.702	5
UniProt:Q96DR7 ARHGEF26	1	ARHGEF26 [cytosol] (R-HSA-8873912)	0.688	3
UniProt:Q13425 SNTB2	1	SNTB2 [plasma membrane] (R-HSA-9630713)	0.669	6
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) SDC2 [Golgi lumen] (R-HSA-2054101) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) Heparan-SDC2 [Golgi lumen] (R-HSA-2076608) Heparan(1)-SDC2 [Golgi lumen] (R-HSA-2076536) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607)	0.667	3
UniProt:Q9H788 SH24A			0.666	4
UniProt:P06463 VE6			0.656	3
UniProt:Q8WXD9 CSKI1			0.639	4
UniProt:Q9P202 WHRN	1	WHRN [cytosol] (R-HSA-204726)	0.623	2
UniProt:Q9UHC6 CNTP2			0.609	2
UniProt:Q9BZL6 PRKD2	1	PRKD2 [cytosol] (R-HSA-58214)	0.592	2
UniProt:P04201 MAS1	1	MAS1 [plasma membrane] (R-HSA-9944591)	0.59	2
UniProt:P22459 KCNA4	1	KCNA4 [plasma membrane] (R-HSA-977474)	0.59	2
UniProt:Q9NS75 CYSLTR2	1	CYSLTR2 [plasma membrane] (R-HSA-416399)	0.59	2
UniProt:P25100 ADRA1D	1	ADRA1D [plasma membrane] (R-HSA-390680)	0.59	2
UniProt:Q9Y2H0 DLGAP4	1	DLGAP4 [plasma membrane] (R-HSA-6794259)	0.59	2
UniProt:Q9Y6W6 DUSP10	2	DUSP10 [cytosol] (R-HSA-5675334) DUSP10 [nucleoplasm] (R-HSA-203793)	0.59	2
UniProt:O15427 SLC16A3	1	SLC16A3 [plasma membrane] (R-HSA-204390)	0.59	2
UniProt:Q63373 NRX1B			0.582	3
UniProt:Q9Y2J0 RP3A			0.581	3
UniProt:Q15375 EPHA7	2	p-Y608,Y614-EPHA7 [plasma membrane] (R-HSA-3928358) EPHA7 [plasma membrane] (R-HSA-2682337)	0.571	2
UniProt:Q8VHK2 CSKI1			0.544	2
UniProt:Q9Y624 F11R	2	F11R [cell junction] (R-HSA-2134498) F11R [plasma membrane] (R-HSA-197845)	0.534	2
UniProt:Q9UM82 SPATA2	1	SPATA2 [cytosol] (R-HSA-9796351)	0.527	2
UniProt:Q9HAP6 LIN7B	2	LIN7B [transport vesicle membrane] (R-HSA-9610415) LIN7B [plasma membrane] (R-HSA-5216107)	0.527	3
UniProt:Q9NUP9 LIN7C	2	LIN7C [plasma membrane] (R-HSA-5216165) LIN7C [transport vesicle membrane] (R-HSA-9610411)	0.527	3
UniProt:P36809 VE6			0.525	3
UniProt:P03409 TAX			0.525	2
UniProt:P03126 VE6			0.525	2
UniProt:Q9IR59 Q9IR59			0.525	2
UniProt:Q81964 Q81964			0.525	3
UniProt:Q12929 EPS8	1	EPS8 [cytosol] (R-HSA-9662382)	0.524	3
UniProt:P41134 ID1	1	ID1 [nucleoplasm] (R-HSA-2534101)	0.508	3

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