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p-Y608,Y614-EPHA7 [plasma membrane]
Stable Identifier
R-HSA-3928358
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Ephrin type-A receptor 7 ecNumber2.7.10.1/ecNumber, EPHA7_HUMAN, EPHA7
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH receptors autophosphorylate (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y608,Y614-EPHA7 [plasma membrane] (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
EPHA binds TIAM1 (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y608,Y614-EPHA7 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y608,Y614-EPHA7 [plasma membrane] (Homo sapiens)
SFKs phosphorylate VAV2,3 (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y608,Y614-EPHA7 [plasma membrane] (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y608,Y614-EPHA7 [plasma membrane] (Homo sapiens)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y608,Y614-EPHA7 [plasma membrane] (Homo sapiens)
VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y608,Y614-EPHA7 [plasma membrane] (Homo sapiens)
p-EPHs bind VAV2,3 (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y608,Y614-EPHA7 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y608,Y614-EPHA7 [plasma membrane] (Homo sapiens)
EPHA-mediated growth cone collapse (Homo sapiens)
NGEF binds EPHA (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y608,Y614-EPHA7 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y608,Y614-EPHA7 [plasma membrane] (Homo sapiens)
NGEF exchanges GTP for GDP on RHOA (Homo sapiens)
EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y608,Y614-EPHA7 [plasma membrane] (Homo sapiens)
SFKs phosphorylate NGEF (Homo sapiens)
EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y608,Y614-EPHA7 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y608,Y614-EPHA7 [plasma membrane] (Homo sapiens)
p-EPHs bind SRC,FYN,YES,LYN (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y608,Y614-EPHA7 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y608,Y614-EPHA7 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15375 EPHA7
Gene Names
EPHA7, EHK3, HEK11
Chain
signal peptide:1-27, chain:28-998
Reference Genes
BioGPS Gene:2045 EPHA7
COSMIC (genes):EPHA7 EPHA7
CTD Gene:2045 EPHA7
dbSNP Gene:2045 EPHA7
ENSEMBL:ENSG00000135333 EPHA7
HGNC:3390 EPHA7
KEGG:hsa:2045 EPHA7
Monarch:2045 EPHA7
NCBI Gene:2045 EPHA7
OMIM:602190 EPHA7
UCSC:Q15375 EPHA7
Reference Transcript
RefSeq:NM_004440.3 EPHA7
RefSeq:XM_005248669.2 EPHA7
RefSeq:NM_001288630.1 EPHA7
RefSeq:NM_001288629.1 EPHA7
Other Identifiers
11726161_at
11726162_at
11726163_at
11726164_at
11761670_at
1485_at
1554629_PM_at
1554629_at
17021792
2045
206852_PM_at
206852_at
229288_PM_at
229288_at
238533_PM_at
238533_at
2965208
2965209
2965210
2965211
2965212
2965213
2965214
2965215
2965216
2965218
2965219
2965220
2965221
2965222
2965223
2965224
2965231
2965232
2965233
2965234
2965235
2965236
2965237
2965244
2965245
2965246
2965247
2965249
2965250
2965251
2965252
2965258
2965259
2965260
46092_at
8128284
82275_at
A_23_P7835
A_24_P226332
A_24_P34031
GE80563
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005003
GO:0005004
GO:0005005
GO:0005515
GO:0005524
GO:0005886
GO:0006468
GO:0006915
GO:0007169
GO:0007399
GO:0007411
GO:0007420
GO:0008046
GO:0012501
GO:0016020
GO:0016310
GO:0016740
GO:0019838
GO:0022407
GO:0030425
GO:0031290
GO:0031952
GO:0043281
GO:0043525
GO:0045499
GO:0048013
GO:0048018
GO:0048671
GO:0048755
GO:0048856
GO:0050730
GO:0050804
GO:0050919
GO:0051402
GO:0051964
GO:0060089
GO:0070372
GO:0072178
GO:0098772
GO:0098978
GO:0099175
GO:0140096
HMNXSV003009617
HMNXSV003011390
HMNXSV003017116
Hs.134736.0.A1_3p_at
Hs.54709.0.S1_3p_at
Hs2.165708.1.S1_3p_at
ILMN_1803637
L36642_at
PH_hs_0004229
TC06001952.hg
g4758281_3p_at
p33909
Participates
as a member of
p-EPHAs [plasma membrane] (Homo sapiens)
Other forms of this molecule
EPHA7 [plasma membrane]
Inferred To
phospho-p-Y608,Y614-EPHA7 [plasma membrane]
(Bos taurus)
phospho-p-Y608,Y614-EPHA7 [plasma membrane]
(Danio rerio)
phospho-p-Y608,Y614-EPHA7 [plasma membrane]
(Gallus gallus)
phospho-p-Y608,Y614-EPHA7 [plasma membrane]
(Mus musculus)
phospho-p-Y608,Y614-EPHA7 [plasma membrane]
(Rattus norvegicus)
phospho-p-Y608,Y614-EPHA7 [plasma membrane]
(Sus scrofa)
phospho-EPHA7 [plasma membrane]
(Canis familiaris)
Modified Residues
Name
O4'-phospho-L-tyrosine at 608
Coordinate
608
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 614
Coordinate
614
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
Guide to Pharmacology - Targets
1827
OpenTargets
ENSG00000135333
ENSEMBL
ENST00000369297
,
ENSG00000135333
,
ENST00000680224
,
ENSP00000358303
,
ENST00000369303
,
ENSP00000506130
,
ENSP00000358309
ZINC - FDA approved
EPHA7_HUMAN
ZINC - Substances
EPHA7_HUMAN
ZINC - Biogenic
EPHA7_HUMAN
ZINC target
Q15375
PRO
Q15375
GlyGen
Q15375
PDB
3H8M
,
3DKO
,
7EED
,
3NRU
,
7EEF
,
7EEC
,
2REI
ZINC - Investigational
EPHA7_HUMAN
IntEnz
2.7.10.1
HPA
ENSG00000135333-EPHA7
GeneCards
EPHA7
Pharos - Targets
Q15375
ZINC - Predictions - Purchasable
EPHA7_HUMAN
HMDB Protein
HMDBP01326
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P34925 RYK
1
RYK [plasma membrane]
(R-HSA-3006746)
0.527
2
UniProt:Q16288 NTRK3
6
p-5Y-NTRK3 [plasma membrane]
(R-HSA-9034718)
NTRK3 [plasma membrane]
(R-HSA-6798240)
NTRK3(496-641) [cytosol]
(R-HSA-9603542)
NTRK3(496-641) [mitochondrial outer membrane]
(R-HSA-9603557)
NTRK3(642-839) [cytosol]
(R-HSA-9603540)
NTRK3(32-495) [plasma membrane]
(R-HSA-9603541)
0.499
2
UniProt:P07333 CSF1R
4
CSF1R [plasma membrane]
(R-HSA-197667)
p-Y561-CSF1R [plasma membrane]
(R-HSA-9733328)
PolyUb,p-Y561-CSF1R [plasma membrane]
(R-HSA-9733335)
PolyUb,p-8Y-CSF1R [plasma membrane]
(R-HSA-389142)
0.499
2
UniProt:P29323 EPHB2
6
p-Y596,Y602-EPHB2 [plasma membrane]
(R-HSA-3928375)
EPHB2 [plasma membrane]
(R-HSA-443809)
EPHB2 (19-?) [extracellular region]
(R-HSA-3928436)
EPHB2 (?-1055) [plasma membrane]
(R-HSA-3928386)
EPHB2 (?-1055) [cytosol]
(R-HSA-3928432)
EPHB2 (?-?) [plasma membrane]
(R-HSA-3928394)
0.499
2
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