LIN7, CASK and APBA1 bind

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In brain, a complex of three proteins form a tripartite complex which may act to couple synaptic vesicle exocytosis to neuronal cell adhesion. Any of the three protein lin7 homologs A, B or C (LIN7A,B or C) can bind to amyloid beta A4 precursor protein-binding family A member 1 (APBA1 aka MINT1) and peripheral plasma membrane protein CASK (aka LIN2) (Butz et al. 1998). All of these proteins contain PDZ domains, not used in complex formation thus able to recruit adhesion molecules, receptors and channels to the complex.

Literature References
PubMed ID Title Journal Year
9753324 A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain

Butz, S, Okamoto, M, S├╝dhof, TC

Cell 1998
Participant Of
Orthologous Events
Cite Us!