In brain, a complex of three proteins form a tripartite complex which may act to couple synaptic vesicle exocytosis to neuronal cell adhesion. Any of the three protein lin7 homologs A, B or C (LIN7A,B or C) can bind to amyloid beta A4 precursor protein-binding family A member 1 (APBA1 aka MINT1) and peripheral plasma membrane protein CASK (aka LIN2) (Butz et al. 1998). All of these proteins contain PDZ domains, not used in complex formation thus able to recruit adhesion molecules, receptors and channels to the complex.
Südhof, TC, Okamoto, M, Butz, S
© 2023 Reactome
