Protein 4.1 binds CASK

Stable Identifier
R-HSA-6797553
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The protein 4.1 family includes four well-defined members: erythroid protein 4.1 (4.1R), the bestknown and characterized member, 4.1G (general), 4.1N (neuronal), and 4.1 B (brain). Protein 4.1N is a neuronal homologue of erythrocyte membrane cytoskeletal protein 4.1 (4.1R). Protein 4.1N can stabilize the plasticity of the neuronal membrane via interactions with the spectrin-actin-based skeleton, integral membrane channels and receptors, and membrane-associated guanylate kinases (Diakowski et al. 2006). This brain-specific protein 4.1N isoform intercts with CASK and recruits actin and spectrin (Biederer & Sudhof 2001).

Literature References
PubMed ID Title Journal Year
11604393 CASK and protein 4.1 support F-actin nucleation on neurexins

Biederer, T, S├╝dhof, TC

J. Biol. Chem. 2001
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