Protein 4.1 binds CASK

Stable Identifier
R-HSA-6797553
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Protein 4.1 binds CASK
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The protein 4.1 family includes four well-defined members: erythroid protein 4.1 (4.1R), the bestknown and characterized member, 4.1G (general), 4.1N (neuronal), and 4.1 B (brain). Protein 4.1N is a neuronal homologue of erythrocyte membrane cytoskeletal protein 4.1 (4.1R). Protein 4.1N can stabilize the plasticity of the neuronal membrane via interactions with the spectrin-actin-based skeleton, integral membrane channels and receptors, and membrane-associated guanylate kinases (Diakowski et al. 2006). This brain-specific protein 4.1N isoform intercts with CASK and recruits actin and spectrin (Biederer & Sudhof 2001).
Literature References
PubMed ID Title Journal Year
11604393 CASK and protein 4.1 support F-actin nucleation on neurexins

Südhof, TC, Biederer, T

J. Biol. Chem. 2001
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Orthologous Events
Protein 4.1 binds CASK (Bos taurus)
Protein 4.1 binds CASK (Caenorhabditis elegans)
Protein 4.1 binds CASK (Canis familiaris)
Protein 4.1 binds CASK (Danio rerio)
Protein 4.1 binds CASK (Drosophila melanogaster)
Protein 4.1 binds CASK (Gallus gallus)
Protein 4.1 binds CASK (Mus musculus)
Protein 4.1 binds CASK (Rattus norvegicus)
Protein 4.1 binds CASK (Sus scrofa)
Protein 4.1 binds CASK (Xenopus tropicalis)
Authored
Garapati, P V  (2015-09-04)
Reviewed
Washbourne, P  (2015-11-09)
Created
Garapati, P V  (2015-09-14)
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