Reactome | ADRA1D [plasma membrane]

ADRA1D [plasma membrane]

Stable Identifier

R-HSA-390680

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Alpha-1D adrenoceptor, RecName: Full=Alpha-1D adrenergic receptor; AltName: Full=Alpha 1D-adrenoreceptor; AltName: Full=Alpha 1D-adrenoceptor; AltName: Full=Alpha-1A adrenergic receptor; AltName: Full=Alpha-adrenergic receptor 1a;
GN Name=ADRA1D; Synonyms=ADRA1A;
OS Homo sapiens, ADA1D_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (12/13) signalling events (Homo sapiens)
      - Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Homo sapiens)
        
        Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)
      - Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Homo sapiens)
        
        Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:G12/13 complex dissociates (Homo sapiens)
        
        GPCRs that activate G12/13 [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Adrenoceptors (Homo sapiens)
        
        ADRA1A,B,D bind ADR,NAd (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)
        
        α1-agonists:ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)
        
        α1-antagonists:ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)
        
        α1-agonists bind ADRA1A,B,D (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)
        
        α1-agonists:ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)
        
        α1-antagonists bind ADRA1A,B,D (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)
        
        α1-antagonists:ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1A,B,D [plasma membrane] (Homo sapiens)
        
        ADRA1D [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P25100 ADRA1D

Gene Names

ADRA1D, ADRA1A

Chain

chain:1-572

Reference Genes

BioGPS Gene:146 ADRA1D

COSMIC - genes:ADRA1A ADRA1D

COSMIC - genes:ADRA1D ADRA1D

CTD Gene:146 ADRA1D

dbSNP Gene:146 ADRA1D

ENSEMBL:ENSG00000171873 ADRA1D

HGNC:280 ADRA1D

KEGG:hsa:146 ADRA1D

Monarch:146 ADRA1D

NCBI Gene:146 ADRA1D

OMIM:104219 ADRA1D

UCSC:P25100 ADRA1D

Reference Transcript

RefSeq:NM_000678.4 ADRA1D

Other Identifiers

11740618_at

11740619_at

146

16916877

210960_PM_at

210960_at

210961_PM_s_at

210961_s_at

36728_at

36729_g_at

3895892

3895893

3895894

3895895

3895902

3895903

3895904

3895905

3895906

8064779

90822_at

A_23_P131924

A_33_P3243023

GE62553

GO:0003013

GO:0004930

GO:0004935

GO:0004937

GO:0005515

GO:0005886

GO:0007165

GO:0007186

GO:0007188

GO:0007200

GO:0007204

GO:0007267

GO:0008284

GO:0016020

GO:0042802

GO:0043410

GO:0045907

GO:0071875

GO:0071880

GO:0150099

HMNXSV003030075

ILMN_1716421

M76446_at

PH_hs_0000065

TC20000584.hg

g177806_3p_at

Participates

as a member of

ADRA1A,B,D [plasma membrane] (Homo sapiens)

Inferred To

ser-5 [plasma membrane] (Caenorhabditis elegans)

Homologues of ADRA1D [plasma membrane] (Sus scrofa)

ADRA1D [plasma membrane] (Bos taurus)

ADRA1D [plasma membrane] (Canis familiaris)

ADRA1D [plasma membrane] (Gallus gallus)

ADRA1D [plasma membrane] (Mus musculus)

ADRA1D [plasma membrane] (Rattus norvegicus)

ADRA1D [plasma membrane] (Sus scrofa)

adra1d [plasma membrane] (Danio rerio)

adra1d [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_000669.1

ZINC - World Drugs

ADA1D_HUMAN

Guide to Pharmacology - Targets

ENSEMBL

ENSP00000368766, ENST00000379453, ENSG00000171873

OpenTargets

ENSG00000171873

ZINC - FDA approved

ADA1D_HUMAN

ZINC - Substances

ADA1D_HUMAN

ZINC - Biogenic

ADA1D_HUMAN

ZINC target

P25100

PRO

P25100

GlyGen

P25100

ZINC - Investigational

ADA1D_HUMAN

ZINC - Metabolites

ADA1D_HUMAN

GeneCards

ADRA1D

HPA

ENSG00000171873-ADRA1D

Pharos - Targets

P25100

ZINC - Predictions - Purchasable

ADA1D_HUMAN

HMDB Protein

HMDBP07435

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.824	22
UniProt:P46939 UTRN	1	UTRN [cytosol] (R-HSA-5216039)	0.773	14
UniProt:Q12959 DLG1	4	DLG1 [plasma membrane] (R-HSA-375977) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593) DLG1 [cytosol] (R-HSA-416332)	0.59	4
UniProt:O14936 CASK	1	CASK [cytosol] (R-HSA-373631)	0.59	2
UniProt:P11532 DMD	1	DMD [cytosol] (R-HSA-390567)	0.527	8

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