Reactome | KCNA4 [plasma membrane]

KCNA4 [plasma membrane]

Stable Identifier

R-HSA-977474

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Potassium voltage-gated channel subfamily A member 4, KCNA4_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Potassium Channels (Homo sapiens)
  - Voltage gated Potassium channels (Homo sapiens)
    - Activation of voltage gated Potassium channels (Homo sapiens)
      - Octamer of Voltage gated K+ channels [plasma membrane] (Homo sapiens)
        
        Voltage gated potassium channel subunits Kv1-12 [plasma membrane] (Homo sapiens)
        
        Kv1 subunits of voltage gated potassium channels [plasma membrane] (Homo sapiens)
        
        KCNA4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P22459 KCNA4

Gene Names

KCNA4, KCNA4L

Chain

chain:1-653

Reference Genes

BioGPS Gene:3739 KCNA4

COSMIC (genes):KCNA4 KCNA4

CTD Gene:3739 KCNA4

dbSNP Gene:3739 KCNA4

ENSEMBL:ENSG00000182255 KCNA4

ENSEMBL_homo_sapiens_GENE:ENSG00000182255.7 KCNA4

HGNC:6222 KCNA4

KEGG Gene (Homo sapiens):3739 KCNA4

Monarch:3739 KCNA4

NCBI Gene:3739 KCNA4

OMIM:176266 KCNA4

UCSC:P22459 KCNA4

Reference Transcript

RefSeq:NM_002233.3 KCNA4

Other Identifiers

11736520_at

16736926

207248_PM_at

207248_at

32344_r_at

3367589

3367590

3367591

3367592

3367593

3367594

3367595

3367596

3367597

3739

66783_at

7947270

A_24_P150023

GE57973

GO:0005215

GO:0005216

GO:0005249

GO:0005251

GO:0005267

GO:0005515

GO:0005886

GO:0006811

GO:0006813

GO:0008076

GO:0016020

GO:0030424

GO:0030955

GO:0034220

GO:0034702

GO:0042995

GO:0043194

GO:0043197

GO:0051260

GO:0055085

GO:0065003

GO:0071805

GO:0099505

GO:0099508

GO:0110165

HMNXSV003049592

ILMN_1651900

M60450_s_at

PH_hs_0026333

TC11001521.hg

g4504816_3p_at

Participates

as a member of

Kv1 subunits of voltage gated potassium channels [plasma membrane] (Homo sapiens)

Inferred To

Sh [plasma membrane] (Drosophila melanogaster)

KCNA4 [plasma membrane] (Bos taurus)

KCNA4 [plasma membrane] (Canis familiaris)

KCNA4 [plasma membrane] (Gallus gallus)

KCNA4 [plasma membrane] (Sus scrofa)

Kcna4 [plasma membrane] (Mus musculus)

Kcna4 [plasma membrane] (Rattus norvegicus)

kcna4 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_002224.1

Guide to Pharmacology - Targets

541

OpenTargets

ENSG00000182255

ZINC - Substances

KCNA4_HUMAN

ZINC target

P22459

PRO

P22459

HPA

ENSG00000182255-KCNA4

GeneCards

P22459

Ensembl

ENSG00000182255, ENSP00000328511, ENST00000328224

Pharos - Targets

P22459

Orphanet

25789

ZINC - Predictions - Purchasable

KCNA4_HUMAN

HMDB Protein

HMDBP10846

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31016 Dlg4	3	Dlg4 [cytosol] (R-RNO-6794248) Dlg4 [endocytic vesicle membrane] (R-RNO-416847) Dlg4 [plasma membrane] (R-RNO-9612601)	0.676	3
UniProt:P21673 SAT1	1	SAT1 [cytosol] (R-HSA-351236)	0.666	4
UniProt:P78352 DLG4	3	DLG4 [cytosol] (R-HSA-6794267) DLG4 [endocytic vesicle membrane] (R-HSA-416847) DLG4 [plasma membrane] (R-HSA-202135)	0.558	2

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