Reactome | DLGAP4 [plasma membrane]

DLGAP4 [plasma membrane]

Stable Identifier

R-HSA-6794259

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Disks large-associated protein 4, DLGP4_HUMAN, GKAP4

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Protein-protein interactions at synapses (Homo sapiens)
  - Neurexins and neuroligins (Homo sapiens)
    - ABP1 binds SHANK proteins (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP4 [plasma membrane] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:DBNL [cytosol] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP4 [plasma membrane] (Homo sapiens)
    - GKAPs bind PSD-95 members (Homo sapiens)
      - GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP4 [plasma membrane] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP4 [plasma membrane] (Homo sapiens)
    - HOMER binds SHANK proteins (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP4 [plasma membrane] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:2xHOMER1,2,3:GRM1,5 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP4 [plasma membrane] (Homo sapiens)
    - SHANK proteins bind GKAPs (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP4 [plasma membrane] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y2H0 DLGAP4

Gene Names

DLGAP4, DAP4, KIAA0964, SAPAP4

Chain

chain:1-992

Reference Genes

BioGPS Gene:22839 DLGAP4

COSMIC (genes):DLGAP4 DLGAP4

CTD Gene:22839 DLGAP4

dbSNP Gene:22839 DLGAP4

ENSEMBL:ENSG00000080845 DLGAP4

HGNC:24476 DLGAP4

KEGG Gene (Homo sapiens):22839 DLGAP4

Monarch:22839 DLGAP4

NCBI Gene:22839 DLGAP4

OMIM:616191 DLGAP4

UCSC:Q9Y2H0 DLGAP4

Reference Transcript

Other Identifiers

0001570348

0002510102

0002510504

11734678_a_at

11743767_a_at

11755111_a_at

16913315

202570_s_at

202571_s_at

202572_s_at

22839

3883820

3883821

3883835

3883842

3883843

3883844

3883847

3883849

3883850

3883851

3883854

3883855

3883856

3883857

3883858

3883859

3883860

3883861

3883879

3883880

3883881

3883888

3883891

3883893

3883894

3883895

3883896

3883897

3883902

3883904

3883905

3883908

3883909

3883910

3883911

3883912

3883913

3883915

41134_at

64007_at

8062293

A_23_P210419

A_24_P216253

GE81972

GO:0003674

GO:0005515

GO:0005575

GO:0005886

GO:0008150

GO:0016020

GO:0023052

GO:0045202

Hs.177425.0.S1_3p_a_at

Hs.177425.0.S2_3p_a_at

ILMN_1749944

ILMN_1754842

ILMN_1786254

PH_hs_0023222

TC20000267.hg

g7662411_3p_a_at

Participant Of

hasMember

GKAP1-4 [plasma membrane]

Inferred To

DLGAP4 [plasma membrane] (Caenorhabditis elegans)

DLGAP4 [plasma membrane] (Canis familiaris)

DLGAP4 [plasma membrane] (Gallus gallus)

DLGAP4 [plasma membrane] (Sus scrofa)

dlgap4 [plasma membrane] (Xenopus tropicalis)

dlgap4b [plasma membrane] (Danio rerio)

vlc [plasma membrane] (Drosophila melanogaster)

Dlgap4 [plasma membrane] (Mus musculus)

Dlgap4 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001035951.1, XP_011526990.1, NP_892118.1, NP_055717.2

OpenTargets

ENSG00000080845

HPA

ENSG00000080845-DLGAP4

GeneCards

Q9Y2H0

Ensembl

ENST00000373907, ENST00000401952, ENSP00000341633, ENSP00000363014, ENSP00000345700, ENSG00000080845, ENST00000339266, ENST00000340491, ENSP00000363023, ENST00000373913, ENSP00000384954

PRO

Q9Y2H0