Reactome | CYSLTR2 [plasma membrane]

CYSLTR2 [plasma membrane]

Stable Identifier

R-HSA-416399

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Cysteinyl leukotriene receptor 2, CLTR2_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        LTC4-CYSLTR mediated IL4 production (Homo sapiens)
        
        LTC4 binds CyslTR1,2 (Homo sapiens)
        
        CYSLTR1,CYSLTR2 [plasma membrane] (Homo sapiens)
        
        CYSLTR2 [plasma membrane] (Homo sapiens)
        
        LTC4:CyslTR1,2 [plasma membrane] (Homo sapiens)
        
        CYSLTR1,CYSLTR2 [plasma membrane] (Homo sapiens)
        
        CYSLTR2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NS75 CYSLTR2

Gene Names

CYSLTR2, CYSLT2, CYSLT2R, PSEC0146

Chain

chain:1-346

Reference Genes

BioGPS Gene:57105 CYSLTR2

COSMIC (genes):CYSLTR2 CYSLTR2

CTD Gene:57105 CYSLTR2

dbSNP Gene:57105 CYSLTR2

ENSEMBL:ENSG00000152207.8 CYSLTR2

HGNC:18274 CYSLTR2

KEGG Gene (Homo sapiens):57105 CYSLTR2

Monarch:57105 CYSLTR2

NCBI Gene:57105 CYSLTR2

OMIM:605666 CYSLTR2

UCSC:Q9NS75 CYSLTR2

Reference Transcript

Other Identifiers

11734945_at

11748485_s_at

11751390_a_at

16774724

220813_PM_at

220813_at

3489139

3489143

3489145

3489146

3489148

3489149

3489150

3489151

3489152

3489153

3489154

3489155

3489156

57105

7969050

A_14_P114786

A_14_P133033

A_23_P319466

GE87344

GO:0001631

GO:0002376

GO:0004930

GO:0004974

GO:0005085

GO:0005515

GO:0005575

GO:0005886

GO:0006955

GO:0007165

GO:0007186

GO:0007218

GO:0008528

GO:0016020

GO:0016021

GO:0023052

GO:0060089

GO:0061737

GO:0071377

GO:0098772

HMNXSV003027993

ILMN_1773204

PH_hs_0013381

TC13000191.hg

g9966850_3p_at

Participates

as an input of

CYSLT2 binds LTC4,LTD4,LTE4 (Homo sapiens)

as a member of

as a component of

CYSLTR2:LTC4,LTD4,LTE4 [plasma membrane] (Homo sapiens)

Inferred To

AstA-R2 [plasma membrane] (Drosophila melanogaster)

CrzR [plasma membrane] (Drosophila melanogaster)

Homologues of CYSLTR2 [plasma membrane] (Caenorhabditis elegans)

Homologues of CYSLTR2 [plasma membrane] (Drosophila melanogaster)

npr-14 [plasma membrane] (Caenorhabditis elegans)

npr-21 [plasma membrane] (Caenorhabditis elegans)

Cysltr2 [plasma membrane] (Mus musculus)

Cysltr2 [plasma membrane] (Rattus norvegicus)

CYSLTR2 [plasma membrane] (Bos taurus)

CYSLTR2 [plasma membrane] (Caenorhabditis elegans)

CYSLTR2 [plasma membrane] (Canis familiaris)

CYSLTR2 [plasma membrane] (Gallus gallus)

CG 13579 [plasma membrane] (Drosophila melanogaster)

npr-27 [plasma membrane] (Caenorhabditis elegans)

zgc:112062 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_001295394.1, NP_001295399.1, NP_001295398.1, NP_001295397.1, NP_001295405.1, NP_065110.1, NP_001295400.1, NP_001295396.1

Guide to Pharmacology - Targets

270

OpenTargets

ENSG00000152207

ZINC - Substances

CLTR2_HUMAN

ZINC target

Q9NS75

PRO

Q9NS75

GeneCards

Q9NS75

HPA

ENSG00000152207-CYSLTR2

Ensembl

ENSP00000282018, ENSP00000508181, ENST00000614739, ENST00000682523, ENST00000282018, ENSG00000152207, ENSP00000477930

Pharos - Targets

Q9NS75

Orphanet

25107

ZINC - Predictions - Purchasable

CLTR2_HUMAN

HMDB Protein

HMDBP02368

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12959 DLG1	4	DLG1 [cytosol] (R-HSA-416332) DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [plasma membrane] (R-HSA-375977)	0.772	7
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q9Y271 CYSLTR1	1	CYSLTR1 [plasma membrane] (R-HSA-416418)	0.471	2