ALK signaling promotes expression of the CD274 gene by stimulating STAT3 binding to its promoter (Marzec et al, 2008). CD274 is a plasma membrane immunosuppressive protein that stimulates immune evasion by binding to its ligand CD279 (reviewed in Kythreotou et al, 2017).
Liu, X, Wasik, MA, Zhang, Q, Wysocka, M, Goradia, A, Marzec, M, Ruggeri, BA, Paessler, M, Raghunath, PN, Wang, HY, Cheng, M
Kythreotou, A, Mauri, FA, Siddique, A, Pinato, DJ, Bower, M
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