CD274 gene expression downstream of ALK signaling

Stable Identifier
R-HSA-9701562
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CD274 gene expression downstream of ALK signaling
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ALK signaling promotes expression of the CD274 gene by stimulating STAT3 binding to its promoter (Marzec et al, 2008). CD274 is a plasma membrane immunosuppressive protein that stimulates immune evasion by binding to its ligand CD279 (reviewed in Kythreotou et al, 2017).
Literature References
PubMed ID Title Journal Year
19088198 Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

Marzec, M, Zhang, Q, Goradia, A, Raghunath, PN, Liu, X, Paessler, M, Wang, HY, Wysocka, M, Cheng, M, Ruggeri, BA, Wasik, MA

Proc. Natl. Acad. Sci. U.S.A. 2008
29097600 PD-L1

Kythreotou, A, Siddique, A, Mauri, FA, Bower, M, Pinato, DJ

J. Clin. Pathol. 2018
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-Y705, S727 STAT3 dimer:CD274 gene [nucleoplasm] (Homo sapiens)
Active Unit
p-Y705,S727-STAT3 dimer [nucleoplasm]
Authored
Rothfels, K  (2021-03-30)
Reviewed
Inghirami, G  (2021-05-04)
Created
Rothfels, K  (2020-09-26)
Cite Us!