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p-T195-ORC6 [cytosol]
Stable Identifier
R-HSA-9734682
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser
Expand all
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Assembly of the ORC complex at the origin of replication (Homo sapiens)
ORC6 is phosphorylated on T195 (Homo sapiens)
p-T195-ORC6:KPNA1,KPNA6:KPNB1 [cytosol] (Homo sapiens)
p-T195-ORC6 [cytosol] (Homo sapiens)
ORC6 translocates to the nucleus (Homo sapiens)
p-T195-ORC6:KPNA1,KPNA6:KPNB1 [cytosol] (Homo sapiens)
p-T195-ORC6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y5N6 ORC6
Gene Names
ORC6, ORC6L
Chain
chain:1-252
Reference Genes
BioGPS Gene:23594 ORC6
COSMIC (genes):ORC6 ORC6
CTD Gene:23594 ORC6
dbSNP Gene:23594 ORC6
ENSEMBL:ENSG00000091651 ORC6
HGNC:17151 ORC6
KEGG:hsa:23594 ORC6
Monarch:23594 ORC6
NCBI Gene:23594 ORC6
OMIM:607213 ORC6
UCSC:Q9Y5N6 ORC6
Reference Transcript
RefSeq:NM_014321.3 ORC6
Other Identifiers
11727837_at
16818600
219105_PM_x_at
219105_x_at
23594
3658927
3658928
3658931
3658932
3658933
3658934
3658935
3658936
3658937
3658938
3658939
3658940
3658941
3658943
3658944
3658945
3658946
53245_r_at
54827_at
54828_f_at
54830_r_at
7995354
A_14_P111114
A_14_P114654
A_14_P122723
A_23_P100341
A_23_P100344
GE58580
GO:0000808
GO:0001650
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0005664
GO:0005829
GO:0006260
GO:0006270
GO:0016020
GO:0043226
HMNXSV003005698
ILMN_1731070
ILMN_2215061
PH_hs_0003454
TC16000425.hg
TC16001530.hg
g7657426_3p_at
Participates
as a component of
p-T195-ORC6:KPNA1,KPNA6:KPNB1 [cytosol] (Homo sapiens)
Other forms of this molecule
ORC6 [nucleoplasm]
ORC6 [cytosol]
p-T195-ORC6 [nucleoplasm]
Inferred To
phospho-orc6 [cytosol]
(Schizosaccharomyces pombe)
phospho-orc6 [cytosol]
(Xenopus tropicalis)
phospho-ORC6 [cytosol]
(Bos taurus)
phospho-ORC6 [cytosol]
(Canis familiaris)
phospho-p-T195-ORC6 [cytosol]
(Gallus gallus)
phospho-p-T195-ORC6 [cytosol]
(Sus scrofa)
phospho-Orc6 [cytosol]
(Drosophila melanogaster)
phospho-Orc6 [cytosol]
(Mus musculus)
phospho-Orc6 [cytosol]
(Rattus norvegicus)
Modified Residues
Name
O-phospho-L-threonine at 195
Coordinate
195
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_055136.1
ENSEMBL
ENSP00000219097
,
ENST00000219097
OpenTargets
ENSG00000091651
HPA
ENSG00000091651-ORC6
PRO
Q9Y5N6
Pharos - Targets
Q9Y5N6
Orphanet
ORC6
PDB
3M03
,
6KVG
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q969G2 LHX4
1
LHX4 [nucleoplasm]
(R-HSA-9010585)
0.781
8
UniProt:Q96R06 SPAG5
0.666
4
UniProt:Q9UBD5 ORC3
1
ORC3 [nucleoplasm]
(R-HSA-68513)
0.656
4
UniProt:Q13416 ORC2
1
ORC2 [nucleoplasm]
(R-HSA-68405)
0.643
3
UniProt:O43929 ORC4
1
ORC4 [nucleoplasm]
(R-HSA-68519)
0.607
2
UniProt:P17096 HMGA1
2
HMGA1 [cytosol]
(R-HSA-3004619)
HMGA1 [nucleoplasm]
(R-HSA-3004623)
0.602
4
UniProt:Q9UFC0 LRWD1
0.527
2
UniProt:O00399 DCTN6
1
DCTN6 [cytosol]
(R-HSA-2029035)
0.527
2
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