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Ub-HIST2H2AB [nucleoplasm]
Stable Identifier
R-HSA-6782490
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
HIST2H2AB, Histone H2A type 2-B, H2A2B_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Metalloprotease DUBs (Homo sapiens)
MYSM1 deubiquitinates Histone H2A (Homo sapiens)
MYSM1:EP300:KAT2B:Ub-histone H2A [nucleoplasm] (Homo sapiens)
Ub-histone H2A [nucleoplasm] (Homo sapiens)
Ub-histone HIST2H2A [nucleoplasm] (Homo sapiens)
Ub-HIST2H2AB [nucleoplasm] (Homo sapiens)
UCH proteinases (Homo sapiens)
Histone H2A is dubiquitinated by the PR-DUB complex (Homo sapiens)
Ub-histone H2A [nucleoplasm] (Homo sapiens)
Ub-histone HIST2H2A [nucleoplasm] (Homo sapiens)
Ub-HIST2H2AB [nucleoplasm] (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP16,USP21 deubiquitinate Histone H2A (Homo sapiens)
USP16,USP21:Ub-histone H2A [nucleoplasm] (Homo sapiens)
Ub-histone H2A [nucleoplasm] (Homo sapiens)
Ub-histone HIST2H2A [nucleoplasm] (Homo sapiens)
Ub-HIST2H2AB [nucleoplasm] (Homo sapiens)
USP3,SAGA deubiquitinate Histone H2A,H2B (Homo sapiens)
USP3,SAGA:Ub-histone H2A, Ub-histone H2B [nucleoplasm] (Homo sapiens)
Ub-histone H2A, Ub-histone H2B [nucleoplasm] (Homo sapiens)
Ub-histone H2A [nucleoplasm] (Homo sapiens)
Ub-histone HIST2H2A [nucleoplasm] (Homo sapiens)
Ub-HIST2H2AB [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IUE6 H2AC21
Gene Names
H2AC21, HIST2H2AB
Chain
initiator methionine:, chain:2-130
Reference Genes
BioGPS Gene:317772 H2AC21
COSMIC (genes):HIST2H2AB H2AC21
CTD Gene:317772 H2AC21
dbSNP Gene:317772 H2AC21
ENSEMBL:ENSG00000184270 HIST2H2AB
HGNC:20508 H2AC21
KEGG:hsa:317772 H2AC21
Monarch:317772 H2AC21
NCBI Gene:317772 H2AC21
OMIM:615014 H2AC21
UCSC:Q8IUE6 H2AC21
Reference Transcript
RefSeq:NM_175065.2 H2AC21
Other Identifiers
11715148_s_at
11715149_x_at
11759284_at
16692636
2357932
2357955
2357956
2434088
2434131
2434132
2434133
2434134
317772
7919642
ADDON002783.hg
A_23_P343927
A_24_P68631
GE508529
GO:0000786
GO:0003674
GO:0003677
GO:0005198
GO:0005515
GO:0005634
GO:0005694
GO:0006325
GO:0008150
GO:0030527
GO:0031492
GO:0031507
GO:0043226
GO:0043229
GO:0046982
GO:0070062
HMNXSV003048996
ILMN_1747589
PH_hs_0020211
TC01003194.hg
Participates
as a member of
Ub-histone HIST2H2A [nucleoplasm] (Homo sapiens)
Other forms of this molecule
K63polyUb-HIST2H2AB [nucleoplasm]
AcK6-HIST2H2AB [nucleoplasm]
Me2aR30-HIST2H2AB [nucleoplasm]
MeR30-HIST2H2AB [nucleoplasm]
Me2aR4-HIST2H2AB [nucleoplasm]
MeR4-HIST2H2AB [nucleoplasm]
Me2aR12-HIST2H2AB [nucleoplasm]
MeR12-HIST2H2AB [nucleoplasm]
HIST2H2AB [nucleoplasm]
AcK-HIST2H2AB [nucleoplasm]
Inferred To
his-65 [nucleoplasm]
(Caenorhabditis elegans)
LOC100485548 [nucleoplasm]
(Xenopus tropicalis)
H2AC21 [nucleoplasm]
(Canis familiaris)
LOC100487632 [nucleoplasm]
(Xenopus tropicalis)
LOC116411633 [nucleoplasm]
(Xenopus tropicalis)
h2ac16 [nucleoplasm]
(Xenopus tropicalis)
LOC116407737 [nucleoplasm]
(Xenopus tropicalis)
LOC100487067 [nucleoplasm]
(Xenopus tropicalis)
H2ac21 [nucleoplasm]
(Mus musculus)
h2ax1 [nucleoplasm]
(Danio rerio)
HTA1 [nucleoplasm]
(Saccharomyces cerevisiae)
Ub-HIST3H2A [nucleoplasm]
(Plasmodium falciparum)
HTA2 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of Ub-HIST2H2AB [nucleoplasm]
(Xenopus tropicalis)
Homologues of Ub-HIST3H2A [nucleoplasm]
(Saccharomyces cerevisiae)
Ub-HIST2H2AB [nucleoplasm]
(Bos taurus)
Ub-HIST2H2AB [nucleoplasm]
(Sus scrofa)
H2AFX [nucleoplasm]
(Gallus gallus)
H2AX [nucleoplasm]
(Dictyostelium discoideum)
His2A:CG33862 [nucleoplasm]
(Drosophila melanogaster)
hta1 [nucleoplasm]
(Schizosaccharomyces pombe)
Modified Residues
Name
ubiquitinylated lysine (monoUb [nucleoplasm]) at 120
Coordinate
120
Modification
monoUb [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_778235.1
ENSEMBL
ENST00000331128
,
ENSP00000332790
OpenTargets
ENSG00000184270
HPA
ENSG00000184270-H2AC21
PRO
Q8IUE6
Pharos - Targets
Q8IUE6
GlyGen
Q8IUE6
HMDB Protein
HMDBP07730
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P17096 HMGA1
2
HMGA1 [cytosol]
(R-HSA-3004619)
HMGA1 [nucleoplasm]
(R-HSA-3004623)
0.669
3
UniProt:Q08945 SSRP1
1
SSRP1 [nucleoplasm]
(R-HSA-65105)
0.527
2
UniProt:P16104 H2AFX
7
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
0.527
3
UniProt:P62241 RPS8
2
RPS8 [cytosol]
(R-HSA-72385)
RPS8 [nucleoplasm]
(R-HSA-6791203)
0.527
2
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