Reactome | PAR-PARP2 [nucleoplasm]

PAR-PARP2 [nucleoplasm]

Stable Identifier

R-HSA-5651715

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

AutoPARylated PARP2

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Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- Base Excision Repair (Homo sapiens)
  - Resolution of Abasic Sites (AP sites) (Homo sapiens)
    - Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)
      - POLB-Dependent Long Patch Base Excision Repair (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PARG dePARylates PARP1,PARP2 (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through MMEJ (alt-NHEJ) (Homo sapiens)
      - PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
- Nucleotide Excision Repair (Homo sapiens)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
    - DNA Damage Recognition in GG-NER (Homo sapiens)
      - PARP1 or PARP2 PARylates DDB2 and autoPARylates (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
    - Dual Incision in GG-NER (Homo sapiens)
      - 3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
      - 5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Homo sapiens)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Homo sapiens)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
      - DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
    - Formation of Incision Complex in GG-NER (Homo sapiens)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Homo sapiens)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Homo sapiens)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
      - CHD1L is recruited to GG-NER site (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
      - ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
      - Formation of the pre-incision complex in GG-NER (Homo sapiens)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
      - RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
      - Recruitment of XPA and release of CAK (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
      - SUMOylation of XPC (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
      - TFIIH binds GG-NER site to form a verification complex (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Homo sapiens)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        PAR-PARP2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UGN5 PARP2

Gene Names

PARP2, ADPRT2, ADPRTL2

Chain

chain:1-583

Reference Genes

BioGPS Gene:10038 PARP2

COSMIC (genes):PARP2 PARP2

CTD Gene:10038 PARP2

dbSNP Gene:10038 PARP2

ENSEMBL:ENSG00000129484 PARP2

HGNC:272 PARP2

KEGG:hsa:10038 PARP2

Monarch:10038 PARP2

NCBI Gene:10038 PARP2

OMIM:607725 PARP2

UCSC:Q9UGN5 PARP2

Reference Transcript

Other Identifiers

10038

11720561_x_at

11733931_a_at

11748434_a_at

16781482

204752_PM_x_at

204752_x_at

214086_PM_s_at

214086_s_at

215773_PM_x_at

215773_x_at

34755_at

34756_g_at

34757_at

3527419

3527421

3527422

3527423

3527425

3527426

3527427

3527428

3527429

3527430

3527431

3527432

3527433

3527434

3527435

3527436

3527437

3527438

3527439

3527440

3527441

3527442

3527443

3527444

3527445

3527446

3527447

3527448

3527449

3527450

3527451

3527452

3527453

3527454

7973036

A_14_P112016

A_23_P163027

GE55975

GO:0003677

GO:0003682

GO:0003684

GO:0003824

GO:0003950

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0006281

GO:0006284

GO:0006302

GO:0006325

GO:0006974

GO:0012501

GO:0016740

GO:0016757

GO:0016779

GO:0022414

GO:0030592

GO:0031491

GO:0043226

GO:0046697

GO:0048856

GO:0061051

GO:0070212

GO:0070213

GO:0072572

GO:0090649

GO:0090734

GO:0097191

GO:0110088

GO:0140096

GO:0140294

GO:0140805

GO:0140806

GO:0140807

GO:0140861

GO:0160004

GO:1990404

HMNXSV003032897

HMNXSV003040048

Hs.24284.2.S1_3p_a_at

ILMN_1757995

ILMN_2354237

PH_hs_0033205

TC14000051.hg

Participates

as a candidate of

PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PARP2 [nucleoplasm]

Inferred To

PARP2 [nucleoplasm] (Bos taurus)

PARP2 [nucleoplasm] (Canis familiaris)

PARP2 [nucleoplasm] (Sus scrofa)

PAR-PARP2 [nucleoplasm] (Caenorhabditis elegans)

PAR-PARP2 [nucleoplasm] (Mus musculus)

adprt1A [nucleoplasm] (Dictyostelium discoideum)

Parp2 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

L-glutamyl-5-poly(ADP-ribose) at unknown position

PsiMod Name

L-glutamyl-5-poly(ADP-ribose)

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl-5-poly(ADP-ribose).

Cross References

Guide to Pharmacology - Targets

2772

OpenTargets

ENSG00000129484

ENSEMBL

ENSP00000517361, ENST00000250416, ENSG00000291803, ENSP00000517362, ENSP00000250416, ENST00000429687, ENSG00000129484, ENST00000708823, ENST00000708822, ENSP00000392972

ZINC - FDA approved

PARP2_HUMAN

ZINC - Substances

PARP2_HUMAN

ZINC target

Q9UGN5

PRO

Q9UGN5

GlyGen

Q9UGN5

PDB

8HLJ, 5DSY, 7AEO, 4TVJ, 8HLQ, 7R59, 8JNY, 5D5K, 6USJ, 4ZZY, 4ZZX, 6X0N, 4PJV, 8HE8, 8HKN, 3KCZ, 3KJD, 8HKO, 6TX3, 8HKS, 6F5B, 6F5F, 6X0L, 6X0M, 6F1K

ZINC - Investigational

PARP2_HUMAN

IntEnz

2.4.2.30

HPA

ENSG00000129484-PARP2

GeneCards

PARP2

Pharos - Targets

Q9UGN5

ZINC - Predictions - Purchasable

PARP2_HUMAN

HMDB Protein

HMDBP00916

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09874 PARP1	4	PARP1 [nucleoplasm] (R-HSA-201568) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617)	0.527	2
UniProt:Q9NTX7 RNF146	1	RNF146 [cytosol] (R-HSA-3640827)	0.527	4

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