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PARP2 [nucleoplasm]
Stable Identifier
R-HSA-174874
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)
POLB-Dependent Long Patch Base Excision Repair (Homo sapiens)
PARG dePARylates PARP1,PARP2 (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP2 [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP2 [nucleoplasm] (Homo sapiens)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP2 [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP2 [nucleoplasm] (Homo sapiens)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP2 [nucleoplasm] (Homo sapiens)
POLB-mediated DNA strand displacement synthesis (Homo sapiens)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP2 [nucleoplasm] (Homo sapiens)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP2 [nucleoplasm] (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through MMEJ (alt-NHEJ) (Homo sapiens)
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Homo sapiens)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP2 [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP2 [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP2 [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP2 [nucleoplasm] (Homo sapiens)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Homo sapiens)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP2 [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP2 [nucleoplasm] (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
DNA Damage Recognition in GG-NER (Homo sapiens)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP2 [nucleoplasm] (Homo sapiens)
PARP1 or PARP2 binds DDB2 at GG-NER site (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UGN5 PARP2
Gene Names
PARP2, ADPRT2, ADPRTL2
Chain
chain:1-583
Reference Genes
BioGPS Gene:10038 PARP2
COSMIC (genes):PARP2 PARP2
CTD Gene:10038 PARP2
dbSNP Gene:10038 PARP2
ENSEMBL:ENSG00000129484 PARP2
HGNC:272 PARP2
KEGG:hsa:10038 PARP2
Monarch:10038 PARP2
NCBI Gene:10038 PARP2
OMIM:607725 PARP2
UCSC:Q9UGN5 PARP2
Reference Transcript
RefSeq:NM_005484.4 PARP2
RefSeq:NM_001042618.2 PARP2
Other Identifiers
10038
11720561_x_at
11733931_a_at
11748434_a_at
16781482
204752_PM_x_at
204752_x_at
214086_PM_s_at
214086_s_at
215773_PM_x_at
215773_x_at
34755_at
34756_g_at
34757_at
3527419
3527421
3527422
3527423
3527425
3527426
3527427
3527428
3527429
3527430
3527431
3527432
3527433
3527434
3527435
3527436
3527437
3527438
3527439
3527440
3527441
3527442
3527443
3527444
3527445
3527446
3527447
3527448
3527449
3527450
3527451
3527452
3527453
3527454
7973036
A_14_P112016
A_23_P163027
GE55975
GO:0003677
GO:0003682
GO:0003684
GO:0003824
GO:0003950
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005829
GO:0006281
GO:0006284
GO:0006302
GO:0006325
GO:0006974
GO:0016740
GO:0016757
GO:0016779
GO:0030592
GO:0031491
GO:0046697
GO:0048856
GO:0061051
GO:0070212
GO:0070213
GO:0071168
GO:0072572
GO:0090649
GO:0090734
GO:0097191
GO:0110088
GO:0140096
GO:0140294
GO:0140805
GO:0140806
GO:0140807
GO:0140861
GO:0160004
GO:1990404
HMNXSV003032897
HMNXSV003040048
Hs.24284.2.S1_3p_a_at
ILMN_1757995
ILMN_2354237
PH_hs_0033205
TC14000051.hg
Participates
as a candidate of
PARP1,PARP2 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PAR-PARP2 [nucleoplasm]
Inferred To
PARP2 [nucleoplasm]
(Bos taurus)
PARP2 [nucleoplasm]
(Canis familiaris)
PARP2 [nucleoplasm]
(Sus scrofa)
parp-1 [nucleoplasm]
(Caenorhabditis elegans)
adprt1A [nucleoplasm]
(Dictyostelium discoideum)
Parp2 [nucleoplasm]
(Mus musculus)
Parp2 [nucleoplasm]
(Rattus norvegicus)
Parp [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_005475.2
,
NP_001036083.1
ZINC - World Drugs
PARP2_HUMAN
Guide to Pharmacology - Targets
2772
OpenTargets
ENSG00000129484
ENSEMBL
ENSP00000392972
,
ENSP00000517362
,
ENSG00000291803
,
ENSP00000517361
,
ENST00000708822
,
ENST00000708823
,
ENSP00000250416
,
ENSG00000129484
,
ENST00000250416
,
ENST00000429687
ZINC - FDA approved
PARP2_HUMAN
ZINC - Substances
PARP2_HUMAN
ZINC target
Q9UGN5
PRO
Q9UGN5
GlyGen
Q9UGN5
PDB
8HLQ
,
7R59
,
8JNY
,
8HLJ
,
6USJ
,
6X0N
,
5DSY
,
7AEO
,
4TVJ
,
6X0L
,
6X0M
,
6F1K
,
8HKO
,
6TX3
,
8HKS
,
6F5B
,
6F5F
,
8HKN
,
3KCZ
,
3KJD
,
4ZZX
,
4ZZY
,
4PJV
,
8HE8
,
5D5K
ZINC - Investigational
PARP2_HUMAN
IntEnz
2.4.2.30
HPA
ENSG00000129484-PARP2
GeneCards
PARP2
Pharos - Targets
Q9UGN5
ZINC - Predictions - Purchasable
PARP2_HUMAN
HMDB Protein
HMDBP00916
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NTX7 RNF146
1
RNF146 [cytosol]
(R-HSA-3640827)
0.643
5
UniProt:P09874 PARP1
4
PARP1 [nucleoplasm]
(R-HSA-201568)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
0.527
2
UniProt:P17096 HMGA1
2
HMGA1 [nucleoplasm]
(R-HSA-3004623)
HMGA1 [cytosol]
(R-HSA-3004619)
0.527
3
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