Reactome | Synthesis of Leukotrienes (LT) and Eoxins (EX)

Synthesis of Leukotrienes (LT) and Eoxins (EX)

Stable Identifier

R-HSA-2142691

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Synthesis of Leukotrienes (LT) and Eoxins (EX)

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Leukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attraction and activation of leukocytes. LTs were discovered in 1938 and were termed the "slow release substance" (SRS) until their structures were determined in 1979 and they were then renamed to leukotrienes. LTs are derived from arachidonate through action by arachidonate 5-lipoxygenase (ALOX5). Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are generated as products derived from leukotriene A4 (LTA4). Eoxins are generated from leukotrienes (LTs) and resemble cysteinyl leukotrienes but have a different three-dimensional structure (Murphy & Gijon 2007, Hammarstrom 1983, MA.Claesson 2009, Vance & Vance 2008, Buczynski et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19244215	Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology Dumlao, DS, Buczynski, MW, Dennis, EA	J Lipid Res	2009
	Biochemistry of Lipids, Lipoproteins and Membranes, 5th Edition Vance, JE, Vance, DE		2008
19130894	On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma Claesson, HE	Prostaglandins Other Lipid Mediat	2009
17623009	Biosynthesis and metabolism of leukotrienes Gijon, MA, Murphy, RC	Biochem J	2007
6311078	Leukotrienes Hammarström, S	Annu Rev Biochem	1983