Reactome | LTA4 is converted to LTC4 by LTC4S

LTA4 is converted to LTC4 by LTC4S

Stable Identifier

R-HSA-266050

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, nuclear envelope

Synonyms

glutathione + leukotriene A4 => leukotriene C4, LTA4 conjugates with glutathione to form LTC4

ReviewStatus

5/5

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Leukotriene A4 conjugates with reduced glutathione (GSH) to produce leukotriene C4 (LTC4). This conjugation is mediated by the homodimeric, perinuclear membrane-bound enzyme leukotriene C4 synthase (LTC4S) (Lam et al. 1994, Welsch et al. 1994). LTC4S differs from cytosolic and microsomal GSH-S-transferases by having a very narrow substrate specificity and the inability to conjugate xenobiotics.

Literature References

PubMed ID	Title	Journal	Year
7937884	Molecular cloning and expression of human leukotriene-C4 synthase Hauser, SD, Isakson, PC, Mathis, KJ, Welsch, DJ, Creely, DP, Krivi, GG	Proc Natl Acad Sci U S A	1994
8052639	Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4 Freeman, GJ, Lam, BK, Austen, KF, Penrose, JF	Proc Natl Acad Sci U S A	1994