Reactome | LTA4 is hydolysed to LTB4 by LTA4H

LTA4 is hydolysed to LTB4 by LTA4H

Stable Identifier

R-HSA-266072

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

H2O + leukotriene A4 => leukotriene B4, LTA4 is hydrolyzed to LTB4

ReviewStatus

5/5

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Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that catalyzes the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) to the dihydroxy acid leukotriene B4 (LTB4) (Radmark et al. 1984, McGee & Fitzpatrick 1985).

Literature References

PubMed ID	Title	Journal	Year
6490615	Leukotriene A4 hydrolase in human leukocytes. Purification and properties Jörnvall, H, Rådmark, O, Shimizu, T, Samuelsson, B	J Biol Chem	1984
2995393	Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes McGee, J, Fitzpatrick, F	J Biol Chem	1985