Reactome | 5S-HpETE is dehydrated to LTA4 by ALOX5

5S-HpETE is dehydrated to LTA4 by ALOX5

Stable Identifier

R-HSA-266051

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, nuclear envelope

Synonyms

(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => H2O + leukotriene A4, Dehydration of 5-HpETE to leukotriene A4

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
    - Biosynthesis of Lipoxins (LX) (Homo sapiens)
      - 5S-HpETE is dehydrated to LTA4 by ALOX5 (Homo sapiens)
  - Fatty acid metabolism (Homo sapiens)
    - Arachidonate metabolism (Homo sapiens)
      - Synthesis of Leukotrienes (LT) and Eoxins (EX) (Homo sapiens)
        
        5S-HpETE is dehydrated to LTA4 by ALOX5 (Homo sapiens)

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In the second step of the formation of leukotriene A4 (LTA4) from arachidonate, arachidonate 5-lipoxygenase (ALOX5) converts 5S-hydroperoxyeicosatetranoic acid (5S-HpETE) to an allylic epoxide, leukotriene A4 (LTA4) (Rouzer et al. 1988, Rouzer & Samuelsson 1987, Rouzer et al. 1986).

Literature References

PubMed ID	Title	Journal	Year
3118366	Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase Rouzer, CA, Samuelsson, B	Proc Natl Acad Sci U S A	1987
3006030	Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities Rouzer, CA, Matsumoto, T, Samuelsson, B	Proc Natl Acad Sci U S A	1986
3164719	Characterization of cloned human leukocyte 5-lipoxygenase expressed in mammalian cells Rouzer, CA, Rands, E, Kargman, S, Jones, RE, Register, RB, Dixon, RA	J Biol Chem	1988