Reactome | 20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3

20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3

Stable Identifier

R-HSA-2161792

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

Synonyms

20-oxo-leukotriene B4 + O2 + reduced (NADPH--hemoprotein reductase) => 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized (NADPH--hemoprotein reductase)

ReviewStatus

5/5

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20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3

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The cytochrome P450s 4F2 (CYP4F2) and F3 (CYP4F3) oxidise 20-aldehyde leukotriene B4 (20cho-LTB4) to form 20-carboxy leukotriene B4 (20cooh-LTB4) (Soberman et al. 1988).

Literature References

PubMed ID	Title	Journal	Year
2836406	The identification and formation of 20-aldehyde leukotriene B4 Soberman, RJ, Sutyak, JP, Okita, RT, Wendelborn, DF, Roberts LJ, 2nd, Austen, KF	J Biol Chem	1988