EXC4 is converted to EXD4 by GGT

Stable Identifier
Reaction [transition]
Homo sapiens
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In an analogous reaction to the formation of leukotriene D4 (LTD4), eoxin C4 (EXC4) is converted to eoxin D4 (EXD4) by a class of gamma-glutamyltransferase (GGT) (Feltenmark et al. 2008, Claesson et al. 2008) which has not yet been identified.

Literature References
PubMed ID Title Journal Year
18184802 Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells

Griffiths, W, Brunnström, A, Edenius, C, Backman, L, Björkholm, M, Gautam, N, Lindbom, L, Claesson, HE, Feltenmark, S

Proc Natl Acad Sci U S A 2008
18647347 Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma

Brunnström, A, Björkholm, M, Johnson, HA, Griffiths, WJ, Sjöberg, J, Porwit, A, Claesson, HE, Schain, F, Feltenmark, S, Andersson, E

FEBS J 2008
Catalyst Activity

eoxin D4 synthase activity of GGT [cytosol]

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