20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH

Stable Identifier
R-HSA-2161979
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
20-oxo-leukotriene B4 + O2 + reduced (NADPH--hemoprotein reductase) => 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
ReviewStatus
5/5
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20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH
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An aldehyde dehydrogenase (ALDH) yet to be cloned in humans has been observed to oxidise 20-aldehyde leukotriene B4 (20cho-LTB4) to form 20-carboxy leukotriene B4 (20cooh-LTB4) (Sutyak et al. 1989).
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Catalyst Activity

20-aldehyde-leukotriene B4 20-monooxygenase activity of ALDH [cytosol]

Physical Entity
ALDH [cytosol] (Homo sapiens)
Activity
20-aldehyde-leukotriene B4 20-monooxygenase activity (GO:0097259)
Cross References
RHEA
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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