Reactome | LTA4 is converted to EXA4 by ALOX15

LTA4 is converted to EXA4 by ALOX15

Stable Identifier

R-HSA-2162019

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Analogous to arachidonate 5-lipoxygenase (ALOX5) biosynthesis of leukotriene A4 (LTA4), arachidonate 15-lipoxygenase (ALOX15) can form an epoxide across C-14 and C-15 to form 14,15-LTA4 aka eoxin A4 (EXA4) (Feltenmark et al. 2008, Claesson et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18184802	Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells Feltenmark, S, Gautam, N, Brunnström, A, Griffiths, W, Backman, L, Edenius, C, Lindbom, L, Björkholm, M, Claesson, HE	Proc Natl Acad Sci U S A	2008
18647347	Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma Claesson, HE, Griffiths, WJ, Brunnström, A, Schain, F, Andersson, E, Feltenmark, S, Johnson, HA, Porwit, A, Sjöberg, J, Björkholm, M	FEBS J	2008