LTB4 is oxidised to 12-oxoLTB4 by PTGR1

Stable Identifier
R-HSA-2161567
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
leukotriene B4 + NADP(+) => 12-oxo-leukotriene B4 + H(+) + NADPH
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
LTB4 is oxidised to 12-oxoLTB4 by PTGR1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Prostaglandin reductase 1 (PTGR1) aka LTB4DH metabolizes eicosanoids by catalysing the oxidation of leukotriene B4 (LTB4) to form 12-oxo-Leukotriene B4 (12-oxoLTB4) aka 12-Keto-LTB4. The gene was originally cloned as leukotriene B4 12-hydroxydehydrogenase (LTB4DH) but was later discovered to have dual functionality as a prostaglandin reductase (Yokomizo et al. 1996). This reaction has been inferred from a reaction in pigs (Yokomizo et al. 1993, Ensor et al. 1998).
Literature References
PubMed ID Title Journal Year
9461497 Purification, cDNA cloning and expression of 15-oxoprostaglandin 13-reductase from pig lung

Tai, HH, Zhang, H, Ensor, CM

Biochem J 1998
8394361 Enzymatic inactivation of leukotriene B4 by a novel enzyme found in the porcine kidney. Purification and properties of leukotriene B4 12-hydroxydehydrogenase

Takahashi, T, Kasama, T, Yokomizo, T, Sato, F, Kobayashi, Y, Taketani, Y, Izumi, T, Shimizu, T

J Biol Chem 1993
8576264 cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase

Kume, K, Uozumi, N, Ogawa, Y, Yokomizo, T, Izumi, T, Shimizu, T

J Biol Chem 1996
Participants
Input
Output
Participates
as an event of
Catalyst Activity

leukotriene B4 12-hydroxy dehydrogenase activity of PTGR1 [cytosol]

Physical Entity
PTGR1 [cytosol] (Homo sapiens)
Activity
leukotriene B4 12-hydroxy dehydrogenase activity (GO:0097257)
Inferred From
LTB4 is oxidised to 12-oxoLTB4 by PTGR1 (Sus scrofa)
Cross References
RHEA
Rhea
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
Cite Us!