LTB4 is oxidised to 12-oxoLTB4 by PTGR1

Stable Identifier
R-HSA-2161567
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
leukotriene B4 + NADP(+) => 12-oxo-leukotriene B4 + H(+) + NADPH
ReviewStatus
5/5
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LTB4 is oxidised to 12-oxoLTB4 by PTGR1
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Prostaglandin reductase 1 (PTGR1) aka LTB4DH metabolizes eicosanoids by catalysing the oxidation of leukotriene B4 (LTB4) to form 12-oxo-Leukotriene B4 (12-oxoLTB4) aka 12-Keto-LTB4. The gene was originally cloned as leukotriene B4 12-hydroxydehydrogenase (LTB4DH) but was later discovered to have dual functionality as a prostaglandin reductase (Yokomizo et al. 1996). This reaction has been inferred from a reaction in pigs (Yokomizo et al. 1993, Ensor et al. 1998).
Literature References
PubMed ID Title Journal Year
9461497 Purification, cDNA cloning and expression of 15-oxoprostaglandin 13-reductase from pig lung

Ensor, CM, Zhang, H, Tai, HH

Biochem J 1998
8394361 Enzymatic inactivation of leukotriene B4 by a novel enzyme found in the porcine kidney. Purification and properties of leukotriene B4 12-hydroxydehydrogenase

Yokomizo, T, Izumi, T, Takahashi, T, Kasama, T, Kobayashi, Y, Sato, F, Taketani, Y, Shimizu, T

J Biol Chem 1993
8576264 cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase

Yokomizo, T, Ogawa, Y, Uozumi, N, Kume, K, Izumi, T, Shimizu, T

J Biol Chem 1996
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Catalyst Activity

leukotriene B4 12-hydroxy dehydrogenase activity of PTGR1 [cytosol]

Physical Entity
PTGR1 [cytosol] (Homo sapiens)
Activity
leukotriene B4 12-hydroxy dehydrogenase activity (GO:0097257)
Inferred From
LTB4 is oxidised to 12-oxoLTB4 by PTGR1 (Sus scrofa)
Cross References
RHEA
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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