Reactome | CYP4F2, 4F3 20-hydroxylate LTB4

CYP4F2, 4F3 20-hydroxylate LTB4

Stable Identifier

R-HSA-211873

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

Synonyms

leukotriene B4 + O2 + reduced (NADPH--hemoprotein reductase) => 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized (NADPH--hemoprotein reductase), CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase I - Functionalization of compounds (Homo sapiens)
    - Cytochrome P450 - arranged by substrate type (Homo sapiens)
      - Eicosanoids (Homo sapiens)
        
        CYP4F2, 4F3 20-hydroxylate LTB4 (Homo sapiens)
- Metabolism of lipids (Homo sapiens)
  - Fatty acid metabolism (Homo sapiens)
    - Arachidonate metabolism (Homo sapiens)
      - Synthesis of Leukotrienes (LT) and Eoxins (EX) (Homo sapiens)
        
        CYP4F2, 4F3 20-hydroxylate LTB4 (Homo sapiens)

General

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Leukotriene B4 (LTB4) is formed from arachidonate and is a potent inflammatory mediator. LTB4's activity is terminated by formation of its omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20OH-LTB4), catalysed by CYP4F2 primarily in human liver (Jin et al. 1998) and also by CYP4F3 (Kikuta et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
9799565	Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4 Jin, R, Lasker, JM, Koop, DR, Raucy, JL	Arch Biochem Biophys	1998
9539102	Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization Kikuta, Y, Tanaka, K, Kusunose, M, Kamada, N, Kato, M, Miyauchi, Y, Yamashita, Y	DNA Cell Biol	1998