LTA4 is hydrolysed to 6t-/6t,12epi-LTB4

Stable Identifier
R-HSA-2161962
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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LTA4 is hydrolysed to 6t-/6t,12epi-LTB4
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Non-enzymatic hydrolysis of the leukotriene A4 (LTA4) epoxide bond creates 6-trans leukotriene B4 (6t-LTB4) and 6-trans,12-epi leukotriene B4 (6t,12epi-LTB4) stereoisomers (Mansour & Agha 1999, Sirois et al. 1985).
Literature References
PubMed ID Title Journal Year
2998743 Metabolism of leukotrienes by adult and fetal human lungs

Chagnon, M, Sirois, P, Borgeat, P, Gentile, J, Gladu, M, Salari, H, Brousseau, Y

Exp Lung Res 1985
10741385 Inhibition of calcium ionophore-stimulated leukotriene generation from intact human neutrophils by captopril

Mansour, M, Agha, A

Res Commun Mol Pathol Pharmacol 1999
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Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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