Reactome | ALOX5 is phosphorylated by MAPKAP2

ALOX5 is phosphorylated by MAPKAP2

Stable Identifier

R-HSA-429016

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ATP + L-seryl-(protein) => ADP + H(+) + O-phospho-L-seryl-(protein)

ReviewStatus

5/5

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Arachidonate 5-lipoxygenase (ALOX5) catalyzes the first step in leukotriene biosynthesis and has a key role in inflammatory processes. ALOX5 is phosphorylated by MAPKAPK2; MAPKAPK2 is stimulated by arachidonate.

Literature References

PubMed ID	Title	Journal	Year
11844797	Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2) Werz, O, Szellas, D, Steinhilber, D, Rådmark, O	J Biol Chem	2002
10779545	5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases Werz, O, Klemm, J, Samuelsson, B, Rådmark, O	Proc Natl Acad Sci U S A	2000