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TGFBR3_mem [plasma membrane]
Stable Identifier
R-HSA-9839336
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
FGFR1 ligand binding and activation (Homo sapiens)
FGFR1b ligand binding and activation (Homo sapiens)
FGFR1b binds to FGF (Homo sapiens)
FGF2:TGFBR3:GIPC1 [plasma membrane] (Homo sapiens)
FGF2:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
FGFR1c ligand binding and activation (Homo sapiens)
FGFR1c binds to FGF (Homo sapiens)
FGF2:TGFBR3:GIPC1 [plasma membrane] (Homo sapiens)
FGF2:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by Activin (Homo sapiens)
Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Homo sapiens)
INHIBIN-A:TGFBR3:ACVR2A [plasma membrane] (Homo sapiens)
INHIBIN-A:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
Activin AB,B binds Activin Receptor ACVR2A,B:ACVR1C (Homo sapiens)
INHIBIN-A:TGFBR3:ACVR2A [plasma membrane] (Homo sapiens)
INHIBIN-A:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
Signaling by BMP (Homo sapiens)
BMP2 binds to the receptor complex (Homo sapiens)
INHIBIN-A:TGFBR3:ACVR2A [plasma membrane] (Homo sapiens)
INHIBIN-A:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Dimeric TGF-beta-1 binds to the receptor (Homo sapiens)
TGFB1,TGFB2:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
TGFB1,TGFB2:TGFBR3:TGFBR2 [plasma membrane] (Homo sapiens)
TGFB1,TGFB2:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
TGFBR2 recruits TGFBR1 (Homo sapiens)
TGFB1,TGFB2:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
TGFB1,TGFB2:TGFBR3:TGFBR2 [plasma membrane] (Homo sapiens)
TGFB1,TGFB2:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
Signaling by TGFBR3 (Homo sapiens)
TGFBR3 PTM regulation (Homo sapiens)
TGFBR3 translocation to plasma membrane (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
TGFBR3_mem cleavage by MMPs (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
TGFBR3 regulates FGF2 signaling (Homo sapiens)
FGF2:TGFBR3 binding to GIPC1 (Homo sapiens)
FGF2:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
FGF2:TGFBR3:GIPC1 [plasma membrane] (Homo sapiens)
FGF2:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
TGFBR3 binding to FGF2 (Homo sapiens)
FGF2:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
TGFBR3 regulates TGF-beta signaling (Homo sapiens)
TGFB1,TGFB2 bind TGFBR3 (Homo sapiens)
TGFB1,TGFB2:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
TGFBR3 binding to GIPC1 (Homo sapiens)
TGFB1,TGFB2:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
TGFB1,TGFB2:TGFBR3:GIPC1 [cytoplasmic side of plasma membrane] (Homo sapiens)
TGFB1,TGFB2:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
TGFBR3 complex binds to TGFBR2 (Homo sapiens)
TGFB1,TGFB2:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
TGFB1,TGFB2:TGFBR3:TGFBR2 [plasma membrane] (Homo sapiens)
TGFB1,TGFB2:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
TGFBR3 degradation (Homo sapiens)
TGFB1,TGFB2:TGFBR3:GIPC1 [cytoplasmic side of plasma membrane] (Homo sapiens)
TGFB1,TGFB2:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
TGFBR3 phosphorylation by TGFBR2 complex (Homo sapiens)
TGFB1,TGFB2:TGFBR3:TGFBR2 [plasma membrane] (Homo sapiens)
TGFB1,TGFB2:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
TGFBR3 regulates activin signaling (Homo sapiens)
Inhibin-A binding to TGFBR3 (Homo sapiens)
INHIBIN-A:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
InhibinA-TGFBR3 binding to ACVR2A (Homo sapiens)
INHIBIN-A:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
INHIBIN-A:TGFBR3:ACVR2A [plasma membrane] (Homo sapiens)
INHIBIN-A:TGFBR3 [plasma membrane] (Homo sapiens)
TGFBR3_mem [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q03167 TGFBR3
Gene Names
TGFBR3
Chain
signal peptide:1-20, chain:21-851
Reference Genes
BioGPS Gene:7049 TGFBR3
COSMIC (genes):TGFBR3 TGFBR3
CTD Gene:7049 TGFBR3
dbSNP Gene:7049 TGFBR3
ENSEMBL:ENSG00000069702 TGFBR3
HGNC:11774 TGFBR3
KEGG:hsa:7049 TGFBR3
Monarch:7049 TGFBR3
NCBI Gene:7049 TGFBR3
OMIM:600742 TGFBR3
UCSC:Q03167 TGFBR3
Reference Transcript
RefSeq:XM_047429255.1 TGFBR3
RefSeq:XM_047429261.1 TGFBR3
RefSeq:XM_047429271.1 TGFBR3
RefSeq:NM_001195684.1 TGFBR3
RefSeq:XM_006710868.2 TGFBR3
RefSeq:XM_047429247.1 TGFBR3
RefSeq:XM_006710867.3 TGFBR3
RefSeq:NM_001195683.2 TGFBR3
RefSeq:XM_047429256.1 TGFBR3
RefSeq:XM_047429254.1 TGFBR3
RefSeq:NM_003243.5 TGFBR3
Other Identifiers
11718900_a_at
11718901_at
11718902_a_at
16689546
1897_at
204731_PM_at
204731_at
226625_PM_at
226625_at
2422724
2422725
2422726
2422727
2422730
2422731
2422732
2422734
2422740
2422743
2422745
2422746
2422748
2422749
2422750
2422752
2422753
2422754
2422758
2422765
2422771
2422786
2422787
2422802
2422803
2422804
2422805
2422806
2422808
2422812
2422813
2422814
2422815
2422816
2422817
53793_at
7049
7917649
A_23_P200780
GE57580
GO:0001666
GO:0001837
GO:0001889
GO:0002376
GO:0003007
GO:0003150
GO:0003151
GO:0003223
GO:0003824
GO:0004888
GO:0005024
GO:0005114
GO:0005160
GO:0005515
GO:0005539
GO:0005576
GO:0005615
GO:0005829
GO:0005886
GO:0006955
GO:0007179
GO:0007181
GO:0008201
GO:0009897
GO:0009986
GO:0010628
GO:0015026
GO:0016020
GO:0016323
GO:0016477
GO:0016740
GO:0017015
GO:0017134
GO:0030154
GO:0030165
GO:0030336
GO:0030509
GO:0030511
GO:0030512
GO:0031100
GO:0032354
GO:0034673
GO:0034695
GO:0034699
GO:0035556
GO:0036122
GO:0043124
GO:0043235
GO:0046332
GO:0048185
GO:0048856
GO:0048870
GO:0050431
GO:0050680
GO:0055010
GO:0060038
GO:0060045
GO:0060216
GO:0060317
GO:0060318
GO:0060347
GO:0060391
GO:0060392
GO:0060412
GO:0060939
GO:0060979
GO:0061384
GO:0062009
GO:0065003
GO:0070062
GO:0070123
GO:0071560
GO:0071944
GO:0090050
GO:0090100
GO:0140096
GO:1901202
HMNXSV003004306
Hs.79059.1.S1_3p_at
ILMN_1784287
L07594_at
PH_hs_0016619
TC01002864.hg
TC01005631.hg
g4507470_3p_at
Participates
as an input of
TGFBR3 degradation (Homo sapiens)
TGFB1,TGFB2 bind TGFBR3 (Homo sapiens)
Inhibin-A binding to TGFBR3 (Homo sapiens)
TGFBR3 binding to FGF2 (Homo sapiens)
TGFBR3_mem cleavage by MMPs (Homo sapiens)
as an output of
TGFBR3 translocation to plasma membrane (Homo sapiens)
as a component of
INHIBIN-A:TGFBR3 [plasma membrane] (Homo sapiens)
TGFB1,TGFB2:TGFBR3 [plasma membrane] (Homo sapiens)
FGF2:TGFBR3 [plasma membrane] (Homo sapiens)
Other forms of this molecule
TGFBR3(21-851) [extracellular region]
TGFBR3(784-851) [basolateral plasma membrane]
TGFBR3 [cytosol]
pT841_TGFBR3 [plasma membrane]
Inferred To
Ghost homologue of TGFBR3_mem [plasma membrane]
(Drosophila melanogaster)
tgfbr3 [plasma membrane]
(Danio rerio)
tgfbr3 [plasma membrane]
(Xenopus tropicalis)
Tgfbr3 [plasma membrane]
(Mus musculus)
Tgfbr3 [plasma membrane]
(Rattus norvegicus)
TGFBR3 [plasma membrane]
(Bos taurus)
TGFBR3 [plasma membrane]
(Canis familiaris)
TGFBR3 [plasma membrane]
(Gallus gallus)
TGFBR3 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001182612.1
,
XP_047285217.1
,
NP_003234.2
,
XP_047285210.1
,
XP_047285203.1
,
XP_047285212.1
,
NP_001182613.1
,
XP_047285227.1
,
XP_047285211.1
,
XP_006710930.1
,
XP_006710931.1
Guide to Pharmacology - Targets
1796
OpenTargets
ENSG00000069702
ENSEMBL
ENSG00000069702
,
ENST00000525962
,
ENSP00000359426
,
ENSP00000212355
,
ENSP00000432638
,
ENSP00000436127
,
ENST00000212355
,
ENST00000465892
,
ENST00000370399
HPA
ENSG00000069702-TGFBR3
GeneCards
TGFBR3
PRO
Q03167
Pharos - Targets
Q03167
GlyGen
Q03167
PDB
7LBG
HMDB Protein
HMDBP14563
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22455 FGFR4
12
p-5Y-FGFR4 [plasma membrane]
(R-HSA-190330)
FGFR4 [plasma membrane]
(R-HSA-189921)
p5Y-FGFR4 Y367C mutant [plasma membrane]
(R-HSA-2011873)
p-5Y-FGFR4 N535D [plasma membrane]
(R-HSA-2038934)
p-5Y-FGFR4 V550L [plasma membrane]
(R-HSA-2038935)
p-5Y-FGFR4 N535K [plasma membrane]
(R-HSA-2038931)
p-5Y-FGFR4 V550E [plasma membrane]
(R-HSA-2038932)
FGFR4 N535D [plasma membrane]
(R-HSA-1614427)
FGFR4 V550L [plasma membrane]
(R-HSA-1614436)
FGFR4 V550E [plasma membrane]
(R-HSA-1614433)
FGFR4 N535K [plasma membrane]
(R-HSA-1614430)
FGFR4 Y367C [plasma membrane]
(R-HSA-1614439)
0.558
2
UniProt:Q8NCB2 CAMKV
0.527
2
UniProt:O14908 GIPC1
1
GIPC1 [cytoplasm]
(R-HSA-9839329)
0.508
3
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