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About
What is Reactome ?
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Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
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Docs
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Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane]
Stable Identifier
R-HSA-1307958
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR4 (Homo sapiens)
Downstream signaling of activated FGFR4 (Homo sapiens)
FRS-mediated FGFR4 signaling (Homo sapiens)
Activated FGFR4 binds FRS2 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4 binds FRS3 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates FRS2 (Homo sapiens)
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-8T-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates FRS3 (Homo sapiens)
Activated FGFR4:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates PPTN11 (Homo sapiens)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS bind to PPTN11 (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS binds GRB2:SOS1 (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
PI-3K cascade:FGFR4 (Homo sapiens)
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Phospholipase C-mediated cascade; FGFR4 (Homo sapiens)
Activated FGFR4 binds PLCG1 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
activated FGFR4:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates PLCG1 (Homo sapiens)
activated FGFR4:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
p-4Y-PLCG1 dissociates from activated FGFR4 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
SHC-mediated cascade:FGFR4 (Homo sapiens)
Activated FGFR4 binds SHC1 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates SHC1 (Homo sapiens)
Activated FGFR4:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGFR4 ligand binding and activation (Homo sapiens)
betaKlotho-mediated ligand binding (Homo sapiens)
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Negative regulation of FGFR4 signaling (Homo sapiens)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 (Homo sapiens)
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-8T-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
CBL ubiquitinates FRS2 and FGFR4 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
Participants
components
x 2
FGF19 [extracellular region]
(Homo sapiens)
x 2
KLB [plasma membrane]
(Homo sapiens)
x 2
p-5Y-FGFR4 [plasma membrane]
(Homo sapiens)
Participates
as a member of
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
as an output of
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Homo sapiens)
Inferred To
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane]
(Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane]
(Caenorhabditis elegans)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane]
(Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane]
(Drosophila melanogaster)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane]
(Gallus gallus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane]
(Mus musculus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane]
(Rattus norvegicus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane]
(Sus scrofa)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane]
(Xenopus tropicalis)
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