MDP elicits a NOD2 response

Stable Identifier
R-HSA-168412
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Muramyl dipeptide (MDP) is an essential structural component of bacterial peptidoglycan (PGN) and the minimal elicitor recognized by NOD2. As MDP is present in nearly all bacteria NOD2 is a general sensor of bacteria. NOD2 has additionally been reported to respond to ssRNA (Sabbah et al. 2009) and play a role in T cell activation (Shaw et al. 2011).

Literature References
PubMed ID Title Journal Year
12527755 Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

Girardin, SE, Boneca, IG, Viala, J, Chamaillard, M, Labigne, A, Thomas, G, Philpott, DJ, Sansonetti, PJ

J Biol Chem 2003
12514169 Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

Inohara, N, Ogura, Y, Fontalba, A, Gutierrez, O, Pons, F, Crespo, J, Fukase, K, Inamura, S, Kusumoto, S, Hashimoto, M, Foster, SJ, Moran, AP, Fernandez-Luna, JL, Nunez, G

J Biol Chem 2003
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