Reactome | CASP1(298-316) [cytosol]

CASP1(298-316) [cytosol]

Stable Identifier

R-HSA-448674

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CASP1 internal fragment, Caspase-1 internal fragment, CASP1, CASP1_HUMAN

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Cell recruitment (pro-inflammatory response) (Homo sapiens)
        
        Purinergic signaling in leishmaniasis infection (Homo sapiens)
        
        CTSG cleaves CASP1(1-404) (Homo sapiens)
        
        CASP1(298-316) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P29466 CASP1

Gene Names

CASP1, IL1BC, IL1BCE

Chain

propeptide:1-119, chain:120-297, propeptide:298-316, chain:317-404

Reference Genes

BioGPS Gene:834 CASP1

COSMIC (genes):CASP1 CASP1

CTD Gene:834 CASP1

dbSNP Gene:834 CASP1

ENSEMBL:ENSG00000137752 CASP1

HGNC:1499 CASP1

KEGG:hsa:834 CASP1

Monarch:834 CASP1

NCBI Gene:834 CASP1

OMIM:147678 CASP1

UCSC:P29466 CASP1

Reference Transcript

Participates

as an output of

CTSG cleaves CASP1(1-404) (Homo sapiens)

Other forms of this molecule

CASP1(1-404) [cytosol]

CASP1(317-404) [cytosol]

CASP1(120-297) [cytosol]

CASP1(1-119) [cytosol]

Inferred To

CASP1 [cytosol] (Bos taurus)

CASP1 [cytosol] (Sus scrofa)

Casp1 [cytosol] (Mus musculus)

Casp1 [cytosol] (Rattus norvegicus)

casp1 [cytosol] (Xenopus tropicalis)

CASP4 [cytosol] (Canis familiaris)

Cross References

Guide to Pharmacology - Targets

1617

OpenTargets

ENSG00000137752

ENSEMBL

ENST00000695719, ENST00000526568, ENSP00000434250, ENST00000436863, ENSP00000433138, ENSP00000434779, ENST00000534497, ENSG00000137752, ENST00000525825, ENSP00000512117, ENST00000531166, ENST00000533400, ENSP00000436875, ENSP00000434303, ENSP00000410076

ZINC - FDA approved

CASP1_HUMAN

ZINC - Substances

CASP1_HUMAN

ZINC - Biogenic

CASP1_HUMAN

ZINC target

P29466

PRO

P29466

PDB

1ICE, 1RWN, 1RWO, 2H48, 6KN0, 1RWP, 8SV1, 8WRA, 7KEU, 5FNA, 2H51, 6BZ9, 2H54, 2FQQ, 6VIE, 5MMV, 1RWX, 2HBR, 2HBQ, 1RWV, 1RWW, 1SC1, 6PZP, 1RWK, 1RWM, 3D6M, 1BMQ, 1SC3, 1SC4, 3D6H, 3NS7, 3E4C, 2H4Y, 2H4W, 2HBZ, 2HBY, 3D6F, 5MTK, 1IBC, 6F6R

ZINC - Investigational

CASP1_HUMAN

ZINC - Metabolites

CASP1_HUMAN

HPA

ENSG00000137752-CASP1

GeneCards

CASP1

Pharos - Targets

P29466

ZINC - Predictions - Purchasable

CASP1_HUMAN

HMDB Protein

HMDBP02162

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9ULZ3 PYCARD	4	PYCARD [cytosol] (R-HSA-561191) PYCARD [secretory granule lumen] (R-HSA-6800957) PYCARD [extracellular region] (R-HSA-6806196) PYCARD [azurophil granule lumen] (R-HSA-6798768)	0.861	11
UniProt:Q9NPP4 NLRC4	1	NLRC4 [cytosol] (R-HSA-561198)	0.743	4
UniProt:Q08AM6 VAC14	3	VAC14 [Golgi membrane] (R-HSA-1806235) VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219)	0.666	4
UniProt:Q9C000 NLRP1	1	NLRP1 [cytosol] (R-HSA-561196)	0.656	3
UniProt:P57730 CAR18			0.598	3
UniProt:Q9HC29 NOD2	1	NOD2 [cytosol] (R-HSA-168411)	0.591	4
UniProt:P57764 GSDMD	13	GSDMD(1-275) [cytosol] (R-HSA-9647641) GSDMD [cytosol] (R-HSA-6801577) GSDMD(269-484) [cytosol] (R-HSA-9710116) GSDMD(1-268) [cytosol] (R-HSA-9710104) S-(2-succinyl)-C191-GSDMD [cytosol] (R-HSA-9716198) GSDMD(276-484) [cytosol] (R-HSA-9647672) dithiocarb-C191-GSDMD(1-275) [cytosol] (R-HSA-9693317) GSDMD(1-87) [cytosol] (R-HSA-9686099) GSDMD(88-484) [cytosol] (R-HSA-9686133) GSDMD [ficolin-1-rich granule lumen] (R-HSA-6801498) GSDMD [extracellular region] (R-HSA-6801576) GSDMD [tertiary granule lumen] (R-HSA-6801501) GSDMD [specific granule lumen] (R-HSA-6801468)	0.591	4
UniProt:Q5XLA6 CAR17			0.591	3
UniProt:P29466 CASP1	5	CASP1(1-404) [cytosol] (R-HSA-448692) CASP1(298-316) [cytosol] (R-HSA-448674) CASP1(317-404) [cytosol] (R-HSA-448704) CASP1(120-297) [cytosol] (R-HSA-448686) CASP1(1-119) [cytosol] (R-HSA-448680)	0.587	2
UniProt:P58753-2 TIRAP			0.581	5
UniProt:P01583 IL1A	4	Myr82K-Myr83K-IL1A [extracellular region] (R-HSA-445746) IL1A(1-112) [cytosol] (R-HSA-449059) 2xMyri-IL1A [cytosol] (R-HSA-449054) IL1A(1-271) [cytosol] (R-HSA-449042)	0.524	3
UniProt:O14862 AIM2	1	AIM2 [cytosol] (R-HSA-874111)	0.488	2

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