Reactome | Ub-TLE1 [nucleoplasm]

Ub-TLE1 [nucleoplasm]

Stable Identifier

R-HSA-3322369

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

ub-TLE1

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External Reference Information

External Reference

UniProt:Q04724 TLE1

Gene Names

TLE1

Chain

chain:1-770

Reference Genes

BioGPS Gene:7088 TLE1

COSMIC (genes):TLE1 TLE1

CTD Gene:7088 TLE1

dbSNP Gene:7088 TLE1

ENSEMBL:ENSG00000196781 TLE1

ENSEMBL:ENSG00000196781.16 TLE1

HGNC:11837 TLE1

KEGG Gene (Homo sapiens):7088 TLE1

Monarch:7088 TLE1

NCBI Gene:7088 TLE1

OMIM:600189 TLE1

UCSC:Q04724 TLE1

Reference Transcript

Other Identifiers

11740414_a_at

17095150

203220_PM_s_at

203220_s_at

203221_PM_at

203221_at

203222_PM_s_at

203222_s_at

3176267

3211580

3211581

3211583

3211585

3211586

3211588

3211590

3211591

3211592

3211597

3211599

3211604

3211605

3211606

3211609

3211613

3211619

3211637

3211639

3211653

3211654

3211659

3211662

3211663

3211664

3979574

41489_at

7088

8161919

A_23_P135239

A_33_P3217719

GE58188

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005829

GO:0006351

GO:0006355

GO:0007165

GO:0009887

GO:0010628

GO:0012501

GO:0016055

GO:0023052

GO:0030178

GO:0042802

GO:0043124

GO:0043226

GO:0045892

GO:0048856

GO:0090090

GO:0140110

GO:0140297

GO:1990907

GO:2000811

HMNXSV003033673

HMNXSV003043281

Hs.28935.0.A1_3p_a_at

Hs.28935.0.A3_3p_at

ILMN_1751572

M99435_at

PH_hs_0024679

TC09001258.hg

g4827027_3p_a_at

Participates

as a component of

ub-TLE1 tetramer [nucleoplasm] (Homo sapiens)

Other forms of this molecule

TLE1 [nucleoplasm]

Inferred To

gro [nucleoplasm] (Drosophila melanogaster)

tle1 [nucleoplasm] (Xenopus tropicalis)

TLE1 [nucleoplasm] (Bos taurus)

TLE1 [nucleoplasm] (Gallus gallus)

TLE1 [nucleoplasm] (Sus scrofa)

Ub-TLE1 [nucleoplasm] (Canis familiaris)

Tle1 [nucleoplasm] (Mus musculus)

Tle1 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

ubiquitinylated lysine at unknown position

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001290033.1, NP_005068.2, NP_001290032.1

OpenTargets

ENSG00000196781

GeneCards

Q04724

HPA

ENSG00000196781-TLE1

Ensembl

ENSG00000196781, ENSP00000365682, ENST00000376499

PRO

Q04724

Pharos - Targets

Q04724

PDB

2CE9, 5MWJ, 4OM2, 4OM3, 2CE8, 1GXR

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13761 RUNX3	7	RUNX3 [nucleoplasm] (R-HSA-8865393) RUNX3 [cytosol] (R-HSA-8937797) Ac-K94,K171-RUNX3 [nucleoplasm] (R-HSA-8951965) PolyUb-K94,K148-RUNX3 [cytosol] (R-HSA-8952400) PolyUb-K94,K148-RUNX3 [nucleoplasm] (R-HSA-8952387) p-Y-RUNX3 [cytosol] (R-HSA-8937805) PolyUb-RUNX3 [nucleoplasm] (R-HSA-8952417)	0.593	3
UniProt:P04183 TK1	1	TK1 [cytosol] (R-HSA-73500)	0.553	2
UniProt:Q9H2X6 HIPK2	3	HIPK2 [nucleoplasm] (R-HSA-3215222) p-HIPK2 [nucleoplasm] (R-HSA-6799375) monoSUMO1-K32-HIPK2 [nucleoplasm] (R-HSA-4090405)	0.544	2
UniProt:Q9HC29 NOD2	1	NOD2 [cytosol] (R-HSA-168411)	0.508	2
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.508	4
UniProt:P15336 ATF2	2	ATF2 [nucleoplasm] (R-HSA-450336) p-T69,T71-ATF2 [nucleoplasm] (R-HSA-450243)	0.462	10