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AAMP binds NOD2
Stable Identifier
R-HSA-9676160
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
NOD1/2 Signaling Pathway (Homo sapiens)
AAMP binds NOD2 (Homo sapiens)
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AAMP (Angio-associated migratory cell protein) binds the human nucleotide-binding domain, leucine rich repeat containing (NLR) family member NOD2. The interaction involves WD40 domains 2-4 of AAMP. NOD2 is critically involved in innate immune protection against a variety of different bacterial pathogens. AAMP negatively regulates, through an unknown mechanism, NOD2-mediated NF-κB activation in HEK293T cells (Bielig et al. 2009).
Literature References
PubMed ID
Title
Journal
Year
19535145
A function for AAMP in Nod2-mediated NF-kappaB activation
Menning, M
,
Bielig, H
,
Philpott, DJ
,
Kutsch, A
,
Zurek, B
,
Sansonetti, PJ
,
Kufer, TA
Mol. Immunol.
2009
Participants
Input
AAMP [cytosol]
(Homo sapiens)
NOD2 [cytosol]
(Homo sapiens)
Output
AAMP:NOD2 [cytosol]
(Homo sapiens)
Participates
as an event of
NOD1/2 Signaling Pathway (Homo sapiens)
Orthologous Events
AAMP binds NOD2 (Bos taurus)
AAMP binds NOD2 (Canis familiaris)
AAMP binds NOD2 (Danio rerio)
AAMP binds NOD2 (Dictyostelium discoideum)
AAMP binds NOD2 (Mus musculus)
AAMP binds NOD2 (Rattus norvegicus)
Authored
Orlic-Milacic, M (2020-01-29)
Reviewed
Liu, X (2020-02-05)
Yao, S (2020-02-05)
Kinsella, BT (2020-02-06)
Mulvaney, EP (2020-02-06)
Created
Orlic-Milacic, M (2020-02-10)
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