AAMP binds NOD2

Stable Identifier
R-HSA-9676160
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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AAMP (Angio-associated migratory cell protein) binds the human nucleotide-binding domain, leucine rich repeat containing (NLR) family member NOD2. The interaction involves WD40 domains 2-4 of AAMP. NOD2 is critically involved in innate immune protection against a variety of different bacterial pathogens. AAMP negatively regulates, through an unknown mechanism, NOD2-mediated NF-κB activation in HEK293T cells (Bielig et al. 2009).

Literature References
PubMed ID Title Journal Year
19535145 A function for AAMP in Nod2-mediated NF-kappaB activation

Bielig, H, Zurek, B, Kutsch, A, Menning, M, Philpott, DJ, Sansonetti, PJ, Kufer, TA

Mol. Immunol. 2009
Participants
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Created