NRAGE activates JNK

Stable Identifier
R-HSA-205132
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NRAGE activates JNK
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The NGF:p75:NRAGE complex promotes threonine and tyrosine phosphorylation, and activation of JNK, by an unknown mechanism.

Participants
Input
Output
Participates
as an event of
Catalyst Activity

JUN kinase activity of NGF:p75NTR:NRAGE [plasma membrane]

Physical Entity
NGF:p75NTR:NRAGE [plasma membrane] (Homo sapiens)
Activity
JUN kinase activity (GO:0004705)
Inferred From
Nrage activates Jnk1 (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-12-06)
Cite Us!