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NRAGE activates JNK
Stable Identifier
R-HSA-205132
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
NRAGE activates JNK (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The NGF:p75:NRAGE complex promotes threonine and tyrosine phosphorylation, and activation of JNK, by an unknown mechanism.
Participants
Input
x 2
ATP [cytosol]
MAPK8 [cytosol]
(Homo sapiens)
Output
x 2
ADP [cytosol]
p-T,Y-MAPK8 [cytosol]
(Homo sapiens)
Participates
as an event of
NRAGE signals death through JNK (Homo sapiens)
Catalyst Activity
JUN kinase activity of NGF:p75NTR:NRAGE [plasma membrane]
Physical Entity
NGF:p75NTR:NRAGE [plasma membrane]
(Homo sapiens)
Activity
JUN kinase activity (GO:0004705)
Inferred From
Nrage activates Jnk1 (Rattus norvegicus)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Friedman, WJ (2008-05-20)
Chao, MV (2008-05-28)
Created
Jassal, B (2007-12-06)
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