MAPK8 phosphorylation

Stable Identifier
R-HSA-9008043
Type
Reaction [omitted]
Species
Homo sapiens
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Interleukin 1 family member 10 (IL1F10, IL 38) is a member of the IL1 family (Lin et al. 2001, Bensen et al. 2001). IL1F10 can bind with X linked interleukin 1 receptor accessory protein like 1 (IL 1RAPL 1) (Mora et al. 2016). Stimulated IL1RAPL1 can activate Mitogen Activated Protein Kinase 8 (MAPK8, JNK1) signaling, which is required for transcription factor AP 1 activation (Born T L et al. 2000, Khan J A et al. 2004). Full length (1 – 152 amino acids) and N terminal truncated (20 – 152 amino acids) IL1F10 can bind with IL1RAPL1. The binding affinity of truncated IL1F10 is much higher than that of the full length. Binding of truncated IL1F10 to IL1RAPL1 results in inhibition of JNK signaling, which consequently leads to IL6 suppression (Mora et al. 2016). This is represented as a black box event because the mechanism of MAPK8 activation by IL1RAPL1 is uncertain.

Literature References
PubMed ID Title Journal Year
20714405 Neuronal JNK pathway activation by IL-1 is mediated through IL1RAPL1, a protein required for development of cognitive functions

Pavlowsky, A, Zanchi, A, Pallotto, M, Giustetto, M, Chelly, J, Sala, C, Billuart, P

Commun Integr Biol 2010
10882729 Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling

Born, TL, Smith, DE, Garka, KE, Renshaw, BR, Bertles, JS, Sims, JE

J. Biol. Chem. 2000
26892022 Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses

Mora, J, Schlemmer, A, Wittig, I, Richter, F, Putyrski, M, Frank, AC, Han, Y, Jung, M, Ernst, A, Weigert, A, Brüne, B

J Mol Cell Biol 2016
15123616 Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL

Khan, JA, Brint, EK, O'Neill, LA, Tong, L

J. Biol. Chem. 2004
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