Reactome | MAPK8 phosphorylation

MAPK8 phosphorylation

Stable Identifier

R-HSA-9008043

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

ReviewStatus

5/5

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Interleukin 1 family member 10 (IL1F10, IL 38) is a member of the IL1 family (Lin et al. 2001, Bensen et al. 2001). IL1F10 can bind with X linked interleukin 1 receptor accessory protein like 1 (IL 1RAPL 1) (Mora et al. 2016). Stimulated IL1RAPL1 can activate Mitogen Activated Protein Kinase 8 (MAPK8, JNK1) signaling, which is required for transcription factor AP 1 activation (Born T L et al. 2000, Khan J A et al. 2004). Full length (1 – 152 amino acids) and N terminal truncated (20 – 152 amino acids) IL1F10 can bind with IL1RAPL1. The binding affinity of truncated IL1F10 is much higher than that of the full length. Binding of truncated IL1F10 to IL1RAPL1 results in inhibition of JNK signaling, which consequently leads to IL6 suppression (Mora et al. 2016). This is represented as a black box event because the mechanism of MAPK8 activation by IL1RAPL1 is uncertain.

Literature References

PubMed ID	Title	Journal	Year
10882729	Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling Born, TL, Smith, DE, Garka, KE, Renshaw, BR, Bertles, JS, Sims, JE	J. Biol. Chem.	2000
20714405	Neuronal JNK pathway activation by IL-1 is mediated through IL1RAPL1, a protein required for development of cognitive functions Pavlowsky, A, Zanchi, A, Pallotto, M, Giustetto, M, Chelly, J, Sala, C, Billuart, P	Commun Integr Biol	2010
26892022	Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses Mora, J, Schlemmer, A, Wittig, I, Richter, F, Putyrski, M, Frank, AC, Han, Y, Jung, M, Ernst, A, Weigert, A, Brüne, B	J Mol Cell Biol	2016
15123616	Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL Khan, JA, Brint, EK, O'Neill, LA, Tong, L	J. Biol. Chem.	2004