Reactome | MAPK8 [cytosol]

MAPK8 [cytosol]

Stable Identifier

R-SSC-168141

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

MAPK8, A0A5G2Q9X6

Locations in the PathwayBrowser

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Immune System (Sus scrofa)

- Cytokine Signaling in Immune system (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-1 family signaling (Sus scrofa)
      - Interleukin-38 signaling (Sus scrofa)
        
        MAPK8 phosphorylation (Sus scrofa)
        
        MAPK8 [cytosol] (Sus scrofa)
    - Interleukin-17 signaling (Sus scrofa)
      - MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Sus scrofa)
        
        MAPK8,9,10 [cytosol] (Sus scrofa)
        
        MAPK8 [cytosol] (Sus scrofa)
- Innate Immune System (Sus scrofa)
  - Fc epsilon receptor (FCERI) signaling (Sus scrofa)
    - FCERI mediated MAPK activation (Sus scrofa)
      - Phosphorylation of human JNKs by activated MKK4/MKK7 (Sus scrofa)
        
        MAPK8,9,10 [cytosol] (Sus scrofa)
        
        MAPK8 [cytosol] (Sus scrofa)
  - Toll-like Receptor Cascades (Sus scrofa)
    - Toll Like Receptor 10 (TLR10) Cascade (Sus scrofa)
      - MyD88 cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Sus scrofa)
        
        MAPK8,9,10 [cytosol] (Sus scrofa)
        
        MAPK8 [cytosol] (Sus scrofa)
    - Toll Like Receptor 2 (TLR2) Cascade (Sus scrofa)
      - Toll Like Receptor TLR1:TLR2 Cascade (Sus scrofa)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Sus scrofa)
        
        MAPK8,9,10 [cytosol] (Sus scrofa)
        
        MAPK8 [cytosol] (Sus scrofa)
      - Toll Like Receptor TLR6:TLR2 Cascade (Sus scrofa)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Sus scrofa)
        
        MAPK8,9,10 [cytosol] (Sus scrofa)
        
        MAPK8 [cytosol] (Sus scrofa)
    - Toll Like Receptor 3 (TLR3) Cascade (Sus scrofa)
      - MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Sus scrofa)
        
        MAPK8,9,10 [cytosol] (Sus scrofa)
        
        MAPK8 [cytosol] (Sus scrofa)
    - Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
      - MyD88-independent TLR4 cascade (Sus scrofa)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Sus scrofa)
        
        MAPK8,9,10 [cytosol] (Sus scrofa)
        
        MAPK8 [cytosol] (Sus scrofa)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Sus scrofa)
        
        MAPK8,9,10 [cytosol] (Sus scrofa)
        
        MAPK8 [cytosol] (Sus scrofa)
    - Toll Like Receptor 5 (TLR5) Cascade (Sus scrofa)
      - MyD88 cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Sus scrofa)
        
        MAPK8,9,10 [cytosol] (Sus scrofa)
        
        MAPK8 [cytosol] (Sus scrofa)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Sus scrofa)
        
        MAPK8,9,10 [cytosol] (Sus scrofa)
        
        MAPK8 [cytosol] (Sus scrofa)
    - Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Sus scrofa)
        
        MAPK8,9,10 [cytosol] (Sus scrofa)
        
        MAPK8 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5G2Q9X6

Gene Names

MAPK8

Reference Genes

BioGPS Gene:396610 MAPK8

ENSEMBL:ENSSSCG00000010380.6

Monarch:396610 MAPK8

NCBI Gene:396610 MAPK8

UCSC:A0A5G2Q9X6 MAPK8

Reference Transcript

Other Identifiers

396610

GO:0000165

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004705

GO:0004707

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0006281

GO:0006302

GO:0006468

GO:0006979

GO:0007254

GO:0009411

GO:0009612

GO:0010628

GO:0016301

GO:0016740

GO:0019899

GO:0019903

GO:0032880

GO:0034198

GO:0034599

GO:0034614

GO:0035033

GO:0042826

GO:0043065

GO:0043066

GO:0043488

GO:0044546

GO:0048511

GO:0051247

GO:0051403

GO:0061157

GO:0065003

GO:0070212

GO:0071222

GO:0071260

GO:0106310

GO:0120283

GO:0140096

GO:1900227

GO:1990166

Ssc.19706.1.S1_at

Ssc.21418.2.A1_at

Ssc.23860.1.A1_at

Participates

as an input of

as a member of

MAPK8,9,10 [cytosol] (Sus scrofa)

Other forms of this molecule

phospho-MAPK8 [cytosol]

phospho-MAPK8 [nucleoplasm]

Inferred From

MAPK8 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSSSCG00000010380, ENSSSCP00000061145, ENSSSCT00000075747

VGNC

90006

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