Reactome | MAP2K4 [cytosol]

MAP2K4 [cytosol]

Stable Identifier

R-HSA-168107

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SEK1, MAP kinase kinase 4, MKK4

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P45985 MAP2K4

Gene Names

MAP2K4, JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1, SKK1

Chain

initiator methionine:, chain:2-399

Reference Genes

BioGPS Gene:6416 MAP2K4

COSMIC (genes):MAP2K4 MAP2K4

CTD Gene:6416 MAP2K4

dbSNP Gene:6416 MAP2K4

ENSEMBL:ENSG00000065559 MAP2K4

ENSEMBL_homo_sapiens_GENE:ENSG00000065559.15 MAP2K4

HGNC:6844 MAP2K4

KEGG Gene (Homo sapiens):6416 MAP2K4

Monarch:6416 MAP2K4

NCBI Gene:6416 MAP2K4

OMIM:601335 MAP2K4

UCSC:P45985 MAP2K4

Reference Transcript

Other Identifiers

11732821_a_at

11732822_a_at

11732823_s_at

11732824_x_at

11754877_s_at

11756943_a_at

16831203

1712_s_at

1845_at

203265_PM_s_at

203265_s_at

203266_PM_s_at

203266_s_at

36910_at

3710682

3710683

3710691

3710699

3710706

3710711

3710713

3710716

3710724

3710726

3710732

3710734

3710735

3710736

3710737

4012521

4012553

4012554

4012556

4012560

4012561

6416

8005029

A_14_P202132

A_32_P6344

GE57743

GO:0000165

GO:0000166

GO:0001934

GO:0002376

GO:0003012

GO:0003824

GO:0004672

GO:0004674

GO:0004708

GO:0004713

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0006260

GO:0006468

GO:0006915

GO:0007165

GO:0007254

GO:0008545

GO:0009611

GO:0012501

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030154

GO:0030424

GO:0032839

GO:0034390

GO:0036211

GO:0036481

GO:0038095

GO:0043065

GO:0043204

GO:0043226

GO:0043525

GO:0045740

GO:0046330

GO:0048856

GO:0051770

GO:0060090

GO:0061049

GO:0071260

GO:0072709

GO:0090398

GO:0106310

GO:0140096

GO:2000672

HMNXSV003025465

Hs.75217.0.S2_3p_a_at

ILMN_2100689

ILMN_2100693

L36870_at

PH_hs_0029190

TC17000155.hg

TC17002052.hg

U17743_s_at

g4506888_3p_a_at

Participates

as an input of

as a member of

Other forms of this molecule

p-S257,T261-MAP2K4 [cytosol]

MAP2K4(1-?) [cytosol]

MAP2K4(?-399) [cytosol]

Inferred To

MAP2K4 [cytosol] (Bos taurus)

MAP2K4 [cytosol] (Caenorhabditis elegans)

MAP2K4 [cytosol] (Canis familiaris)

MAP2K4 [cytosol] (Danio rerio)

MAP2K4 [cytosol] (Dictyostelium discoideum)

MAP2K4 [cytosol] (Drosophila melanogaster)

MAP2K4 [cytosol] (Gallus gallus)

MAP2K4 [cytosol] (Mus musculus)

MAP2K4 [cytosol] (Rattus norvegicus)

MAP2K4 [cytosol] (Sus scrofa)

MAP2K4 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001268364.1, NP_003001.1

ZINC - World Drugs

MP2K4_HUMAN

Guide to Pharmacology - Targets

2065

OpenTargets

ENSG00000065559

ZINC - FDA approved

MP2K4_HUMAN

ZINC - Substances

MP2K4_HUMAN

ZINC target

P45985

ZINC - Biogenic

MP2K4_HUMAN

PRO

P45985

PDB

3ALO, 3ALN, 3VUT

ZINC - Investigational

MP2K4_HUMAN

IntEnz

2.7.12.2

GeneCards

P45985

HPA

ENSG00000065559-MAP2K4

Ensembl

ENSP00000410402, ENSG00000065559, ENST00000415385, ENST00000353533, ENSP00000262445

Pharos - Targets

P45985

ZINC - Predictions - Purchasable

MP2K4_HUMAN

HMDB Protein

HMDBP01366

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P45983 MAPK8	3	MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.688	3
UniProt:Q13233 MAP3K1	2	MAP3K1 [cytosol] (R-HSA-166866) p-T1400,T1412-MAP3K1 [cytosol] (R-HSA-2685607)	0.602	3
UniProt:P45984 MAPK9	3	MAPK9 [cytosol] (R-HSA-450355) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319)	0.547	2

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