GTP-bound RAC contributes to JNK activation

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R-HSA-205136
Type
Reaction [transition]
Species
Homo sapiens
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RAC activation was described as essential for p75NTR to induce JNK and apoptosis in cortical oligodendrocytes. The simultaneous activation of TRKA counteracts the apoptotic action of p75, by modulating the kinetics of p75-mediated RAC activation.

Literature References
PubMed ID Title Journal Year
9520479 The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death

Bazenet, CE, Mota, MA, Rubin, LL

Proc Natl Acad Sci U S A 1998
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