NRIF and TRAF6 may activate JNK

Stable Identifier
R-HSA-204949
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NRIF and TRAF6 appear to cooperate in JNK activation. TRAF6 is involved both in JNK activation and in NF-kB activation. Although the NRIF:TRAF6 interaction enhances by threefold the TRAF6-mediated activation of JNK, it only modestly affects TRAF6-mediated activation of NF-kB.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
JUN kinase activity of NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane]
Physical Entity
Activity
Inferred From
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Reviewed
Created