NRIF and TRAF6 may activate JNK

Stable Identifier
R-HSA-204949
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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NRIF and TRAF6 may activate JNK
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NRIF and TRAF6 appear to cooperate in JNK activation. TRAF6 is involved both in JNK activation and in NF-kB activation. Although the NRIF:TRAF6 interaction enhances by threefold the TRAF6-mediated activation of JNK, it only modestly affects TRAF6-mediated activation of NF-kB.
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Catalyst Activity

JUN kinase activity of NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane]

Physical Entity
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Homo sapiens)
Activity
JUN kinase activity (GO:0004705)
Inferred From
NRIF and TRAF6 may activate JNK (Mus musculus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-12-06)
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