Reactome | Rbm8a [cytosol]

Rbm8a [cytosol]

Stable Identifier

R-MMU-162462

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

RBM8A, Q9CWZ3

Locations in the PathwayBrowser

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Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        Magoh-Y14 complex [cytosol] (Mus musculus)
        
        Rbm8a [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        Magoh-Y14 complex [cytosol] (Mus musculus)
        
        Rbm8a [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        Magoh-Y14 complex [cytosol] (Mus musculus)
        
        Rbm8a [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        Magoh-Y14 complex [cytosol] (Mus musculus)
        
        Rbm8a [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        Magoh-Y14 complex [cytosol] (Mus musculus)
        
        Rbm8a [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        Magoh-Y14 complex [cytosol] (Mus musculus)
        
        Rbm8a [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        Magoh-Y14 complex [cytosol] (Mus musculus)
        
        Rbm8a [cytosol] (Mus musculus)
- Processing of Capped Intron-Containing Pre-mRNA (Mus musculus)
  - Transport of Mature Transcript to Cytoplasm (Mus musculus)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Mus musculus)
      - Transport of the export-competent mRNP complex through the NPC (Mus musculus)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Mus musculus)
        
        EJC [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        Magoh-Y14 complex [cytosol] (Mus musculus)
        
        Rbm8a [cytosol] (Mus musculus)
      - mRNP complex dissociates from cytosolic face of NPC (Mus musculus)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Mus musculus)
        
        EJC [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        Magoh-Y14 complex [cytosol] (Mus musculus)
        
        Rbm8a [cytosol] (Mus musculus)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Mus musculus)
        
        EJC [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        Magoh-Y14 complex [cytosol] (Mus musculus)
        
        Rbm8a [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9CWZ3

Gene Names

Rbm8a

Reference Genes

BioGPS Gene:60365 Rbm8a

ENSEMBL:ENSMUSG00000038374

ENSEMBL:ENSMUSG00000038374.11 Rbm8a

KEGG Gene (Mus musculus):60365 Rbm8a

Monarch:60365 Rbm8a

NCBI Gene:60365 Rbm8a

UCSC:Q9CWZ3 Rbm8a

Reference Transcript

Other Identifiers

10494452

129774_f_at

1418119_at

1418120_at

17400630

4418899

4444731

4565560

4623794

4713067

4729634

4811852

4884043

5051409

5116380

5202269

5235073

5289199

5400824

5498325

60365

97254_at

A_52_P355014

A_52_P452578

GE1581597

GE40987

GO:0000184

GO:0000381

GO:0000398

GO:0003676

GO:0003723

GO:0003729

GO:0005634

GO:0005654

GO:0005681

GO:0005737

GO:0005829

GO:0006396

GO:0006397

GO:0006406

GO:0006417

GO:0006913

GO:0008380

GO:0016071

GO:0016607

GO:0030425

GO:0035145

GO:0043025

GO:0043226

GO:0050684

GO:0051028

GO:0071006

GO:0071013

GO:0110165

GO:1990501

GO:2000622

ILMN_1252850

ILMN_2609615

ILMN_2777900

Msa.22528.0_s_at

mMC005065

mMC024481

mMR026980

Participates

as a component of

Magoh-Y14 complex [cytosol] (Mus musculus)

Other forms of this molecule

Rbm8a [nucleoplasm]

Inferred From

RBM8A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001095877.1, NP_080151.2

Ensembl

ENSMUSP00000143190, ENSMUSG00000038374, ENSMUSP00000044548, ENSMUST00000196456, ENSMUST00000048915

PRO

Q9CWZ3

MGI

1913129

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