Reactome | CASC3 [cytosol]

CASC3 [cytosol]

Stable Identifier

R-HSA-927807

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein CASC3, CASC3_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Regulation of expression of SLITs and ROBOs (Homo sapiens)
        
        Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
        
        Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - Transport of Mature Transcript to Cytoplasm (Homo sapiens)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
      - Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
      - mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15234 CASC3

Gene Names

CASC3, MLN51

Chain

chain:1-703

Reference Genes

BioGPS Gene:22794 CASC3

COSMIC (genes):CASC3 CASC3

CTD Gene:22794 CASC3

dbSNP Gene:22794 CASC3

ENSEMBL:ENSG00000108349 CASC3

ENSEMBL:ENSG00000108349.17 CASC3

HGNC:17040 CASC3

KEGG Gene (Homo sapiens):22794 CASC3

Monarch:22794 CASC3

NCBI Gene:22794 CASC3

OMIM:606504 CASC3

UCSC:O15234 CASC3

Reference Transcript

Other Identifiers

11715736_s_at

11715737_at

11752377_a_at

16833996

207842_PM_s_at

207842_s_at

22794

3720784

3720785

3720786

3720788

3720789

3720796

3720797

3720798

3720799

3720800

3720801

3720802

3720804

3720805

3720807

3720809

3720810

3720812

3720813

38437_at

8007028

A_23_P374284

A_23_P374288

A_24_P125353

GE60060

GO:0000184

GO:0000398

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005635

GO:0005654

GO:0005681

GO:0005737

GO:0005829

GO:0006397

GO:0006406

GO:0006417

GO:0006913

GO:0008298

GO:0008380

GO:0010494

GO:0016071

GO:0016607

GO:0019899

GO:0030425

GO:0031625

GO:0031965

GO:0035145

GO:0036464

GO:0042802

GO:0042995

GO:0043226

GO:0048471

GO:0051028

GO:0071006

GO:1990904

GO:2000622

HMNXSV003008421

ILMN_1665004

PH_hs_0004765

TC17000490.hg

X80199_at

g6678887_3p_a_at

Participates

as a component of

Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)

Other forms of this molecule

CASC3 [nucleoplasm]

Inferred To

casc3 [cytosol] (Danio rerio)

casc3 [cytosol] (Xenopus tropicalis)

Ghost homologue of CASC3 [cytosol] (Dictyostelium discoideum)

Ghost homologue of CASC3 [cytosol] (Plasmodium falciparum)

Ghost homologue of CASC3 [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of CASC3 [cytosol] (Schizosaccharomyces pombe)

btz [cytosol] (Drosophila melanogaster)

casc-3 [cytosol] (Caenorhabditis elegans)

CASC3 [cytosol] (Bos taurus)

CASC3 [cytosol] (Canis familiaris)

CASC3 [cytosol] (Gallus gallus)

CASC3 [cytosol] (Sus scrofa)

Casc3 [cytosol] (Mus musculus)

Casc3 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_031385.2, XP_005257220.1

OpenTargets

ENSG00000108349

GeneCards

O15234

HPA

ENSG00000108349-CASC3

Ensembl

ENST00000264645, ENSG00000108349, ENSP00000264645

PRO

O15234

Pharos - Targets

O15234

PDB

7W59, 2XB2, 5XJC, 7W5B, 5YZG, 2J0S, 2HYI, 2J0U, 3EX7, 2J0Q, 6ICZ, 7W5A

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38919 EIF4A3	2	EIF4A3 [cytosol] (R-HSA-927868) EIF4A3 [nucleoplasm] (R-HSA-8849149)	0.977	33
UniProt:P61326 MAGOH	1	MAGOH [nucleoplasm] (R-HSA-156658)	0.959	24
UniProt:Q9Y5S9-1 RBM8A			0.863	12
UniProt:Q9Y5S9 RBM8A	2	RBM8A [cytosol] (R-HSA-162462) RBM8A [nucleoplasm] (R-HSA-156659)	0.813	5
UniProt:Q9BZI7-2 UPF3B			0.79	10
UniProt:Q9HAU5 UPF2	1	UPF2 [cytosol] (R-HSA-927799)	0.704	7
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.698	5
UniProt:Q9BZI7 UPF3B	2	UPF3B [nucleoplasm] (R-HSA-156776) UPF3B [cytosol] (R-HSA-159258)	0.643	3
UniProt:Q3LI66 KRTAP6-2	1	KRTAP6-2 [cytosol] (R-HSA-6810261)	0.556	5

Cite Us!