Reactome | CASC3 [cytosol]

CASC3 [cytosol]

Stable Identifier

R-HSA-927807

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein CASC3, CASC3_HUMAN

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Regulation of expression of SLITs and ROBOs (Homo sapiens)
        
        Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
        
        Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - Transport of Mature Transcript to Cytoplasm (Homo sapiens)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
      - Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
      - mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        CASC3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15234 CASC3

Gene Names

CASC3, MLN51

Chain

chain:1-703

Reference Genes

BioGPS Gene:22794 CASC3

COSMIC (genes):CASC3 CASC3

CTD Gene:22794 CASC3

dbSNP Gene:22794 CASC3

ENSEMBL:ENSG00000108349 CASC3

HGNC:17040 CASC3

KEGG:hsa:22794 CASC3

Monarch:22794 CASC3

NCBI Gene:22794 CASC3

OMIM:606504 CASC3

UCSC:O15234 CASC3

Reference Transcript

Other Identifiers

11715736_s_at

11715737_at

11752377_a_at

16833996

207842_PM_s_at

207842_s_at

22794

3720781

3720782

3720783

3720784

3720785

3720786

3720787

3720788

3720789

3720796

3720797

3720798

3720799

3720800

3720801

3720802

3720803

3720804

3720805

3720806

3720807

3720808

3720809

3720810

3720811

3720812

3720813

3720816

38437_at

8007028

A_23_P374284

A_23_P374288

A_24_P125353

GE60060

GO:0000184

GO:0000398

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005737

GO:0005829

GO:0006397

GO:0006406

GO:0006417

GO:0006913

GO:0008298

GO:0008380

GO:0010494

GO:0016071

GO:0016607

GO:0019899

GO:0030425

GO:0031625

GO:0031965

GO:0035145

GO:0036464

GO:0042802

GO:0042995

GO:0043226

GO:0048471

GO:0051028

GO:0071006

GO:1990904

GO:2000622

HMNXSV003008421

HMNXSV003041509

ILMN_1665004

PH_hs_0004765

TC17000490.hg

X80199_at

g6678887_3p_a_at

Participates

as a component of

Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)

Other forms of this molecule

CASC3 [nucleoplasm]

Inferred To

casc3 [cytosol] (Danio rerio)

casc3 [cytosol] (Xenopus tropicalis)

Ghost homologue of CASC3 [cytosol] (Dictyostelium discoideum)

Ghost homologue of CASC3 [cytosol] (Plasmodium falciparum)

Ghost homologue of CASC3 [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of CASC3 [cytosol] (Schizosaccharomyces pombe)

btz [cytosol] (Drosophila melanogaster)

casc-3 [cytosol] (Caenorhabditis elegans)

CASC3 [cytosol] (Bos taurus)

CASC3 [cytosol] (Canis familiaris)

CASC3 [cytosol] (Gallus gallus)

CASC3 [cytosol] (Sus scrofa)

Casc3 [cytosol] (Mus musculus)

Casc3 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

XP_054171455.1, XP_005257220.1, NP_031385.2

OpenTargets

ENSG00000108349

ENSEMBL

ENST00000264645, ENSG00000108349, ENSP00000264645

HPA

ENSG00000108349-CASC3

GeneCards

CASC3

PRO

O15234

Pharos - Targets

O15234

GlyGen

O15234

PDB

2HYI, 6ICZ, 7W59, 3EX7, 5YZG, 2J0U, 2J0Q, 2J0S, 8I0W, 7W5A, 5XJC, 7W5B, 2XB2

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38919 EIF4A3	2	EIF4A3 [cytosol] (R-HSA-927868) EIF4A3 [nucleoplasm] (R-HSA-8849149)	0.982	39
UniProt:P61326 MAGOH	1	MAGOH [nucleoplasm] (R-HSA-156658)	0.968	28
UniProt:Q9Y5S9 RBM8A	2	RBM8A [nucleoplasm] (R-HSA-156659) RBM8A [cytosol] (R-HSA-162462)	0.899	7
UniProt:Q9Y5S9-1 RBM8A			0.863	12
UniProt:Q9BZI7-2 UPF3B			0.79	10
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.766	6
UniProt:Q9HAU5 UPF2	1	UPF2 [cytosol] (R-HSA-927799)	0.704	7
UniProt:Q9H307 PNN	1	PNN [nucleoplasm] (R-HSA-9770779)	0.643	3
UniProt:Q9BZI7 UPF3B	2	UPF3B [cytosol] (R-HSA-159258) UPF3B [nucleoplasm] (R-HSA-156776)	0.643	3
UniProt:Q9BRP8 PYM1			0.621	4
UniProt:Q3LI66 KRTAP6-2	1	KRTAP6-2 [cytosol] (R-HSA-6810261)	0.556	5
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.527	2
UniProt:Q8TAD8 SNIP1	1	SNIP1 [nucleoplasm] (R-HSA-3222315)	0.527	2
UniProt:P84103 SRSF3	1	SRSF3 [nucleoplasm] (R-HSA-72035)	0.527	2
UniProt:Q8N6W0 CELF5			0.527	2
UniProt:Q8IYD1 GSPT2	1	GSPT2 [cytosol] (R-HSA-143379)	0.527	3
UniProt:Q9ULR5 PAI2B			0.527	2
UniProt:Q9Y383 LC7L2			0.527	2
UniProt:Q12926 ELAVL2	1	ELAVL2 [nucleoplasm] (R-HSA-8850864)	0.527	2
UniProt:Q9BUT9 MCRI2			0.527	2
UniProt:O95302 FKBP9	1	FKBP9 [cytosol] (R-HSA-391306)	0.527	2
UniProt:Q8WTV1 THAP3			0.527	2
UniProt:Q9GZR2 REXO4			0.527	2
UniProt:Q7Z417 NUFP2			0.527	2
UniProt:Q9UBU9 NXF1	2	NXF1 [nucleoplasm] (R-HSA-111690) NXF1 [cytosol] (R-HSA-156481)	0.527	2
UniProt:Q15287 RNPS1	2	RNPS1 [nucleoplasm] (R-HSA-156778) RNPS1 [cytosol] (R-HSA-159256)	0.527	3
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2