PXLP-ALAS1 [mitochondrial matrix]

Stable Identifier
R-HSA-1022086
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
5-aminolevulinate synthase, non-specific (pyridoxal phosphate cofactor), HEM1_HUMAN, ALAS1, 5-aminolevulinate synthase, non-specific, mitochondrial
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P13196 ALAS1
Gene Names
ALAS1, ALAS3, ALASH, OK/SW-cl.121
Chain
transit peptide:1-56, chain:57-640
Reference Genes
BioGPS Gene:211 ALAS1
COSMIC (genes):ALAS1 ALAS1
CTD Gene:211 ALAS1
dbSNP Gene:211 ALAS1
ENSEMBL:ENSG00000023330 ALAS1
ENSEMBL_homo_sapiens_GENE:ENSG00000023330.15 ALAS1
HGNC:396 ALAS1
KEGG Gene (Homo sapiens):211 ALAS1
Monarch:211 ALAS1
NCBI Gene:211 ALAS1
OMIM:125290 ALAS1
Reference Transcript
Other Identifiers
11719328_a_at
11719329_x_at
11733041_a_at
11750973_a_at
16941344
205633_PM_s_at
205633_s_at
211
2623526
2623527
2623529
2623530
2623532
2623535
2623537
2623538
2623539
2623540
2623542
2623543
2623545
2623546
2623547
2623551
2623552
2623553
37674_at
8080184
A_23_P57877
A_24_P191588
GE59815
GE60231
GO:0002376
GO:0003824
GO:0003870
GO:0005515
GO:0005634
GO:0005654
GO:0005739
GO:0005743
GO:0005759
GO:0005829
GO:0006778
GO:0006782
GO:0006783
GO:0006784
GO:0006785
GO:0009058
GO:0016020
GO:0016740
GO:0016746
GO:0030154
GO:0030170
GO:0033014
GO:0042541
GO:0042802
GO:0043226
GO:0048034
GO:0048821
GO:0048856
GO:1903412
HMNXSV003050344
ILMN_1700047
ILMN_1728309
ILMN_2385647
PH_hs_0026670
PH_hs_0031344
TC03000329.hg
Y00451_s_at
g4502024_3p_a_at
Participates
as a component of
Other forms of this molecule
ALAS1 [mitochondrial matrix]
Inferred To
Alas [mitochondrial matrix] (Drosophila melanogaster)
alas1 [mitochondrial matrix] (Danio rerio)
alas1 [mitochondrial matrix] (Xenopus tropicalis)
PXLP-ALAS1 [mitochondrial matrix] (Mus musculus)
PXLP-ALAS1 [mitochondrial matrix] (Plasmodium falciparum)
PXLP-ALAS1 [mitochondrial matrix] (Rattus norvegicus)
PXLP-ALAS1 [mitochondrial matrix] (Saccharomyces cerevisiae)
PXLP-ALAS1 [mitochondrial matrix] (Schizosaccharomyces pombe)
hemA [mitochondrial matrix] (Dictyostelium discoideum)
ALAS1 [mitochondrial matrix] (Bos taurus)
ALAS1 [mitochondrial matrix] (Canis familiaris)
ALAS1 [mitochondrial matrix] (Gallus gallus)
ALAS1 [mitochondrial matrix] (Sus scrofa)
Modified Residues
Name
N6-pyridoxal phosphate-L-lysine at unknown position
PsiMod Name
N6-pyridoxal phosphate-L-lysine [MOD:00128]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.
Cross References
RefSeq
OpenTargets
IntEnz
HPA
GeneCards
Ensembl
PRO
Pharos - Targets
Orphanet
HMDB Protein
Interactors (62)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q8WTR2 DUS19      0.871 9
 UniProt:Q6P1J9 CDC73  1 0.781 9
 UniProt:P63313 TYB10      0.718 6
 UniProt:Q17RB8 LONRF1  1 0.718 6
 UniProt:Q17RB0 RTL8B      0.718 6
 UniProt:Q8TBZ8 ZNF564  1 0.718 6
 UniProt:Q8WW24 TEKT4      0.718 6
 UniProt:Q9Y473 ZNF175  1 0.718 6
 UniProt:O60437 PPL  2 0.718 6
 UniProt:Q6PF15 KLH35      0.675 4
 UniProt:Q9Y2S7 PDIP2      0.666 4
 UniProt:P13196 ALAS1  2 0.666 4
 UniProt:Q96L91 EP400  1 0.666 4
 UniProt:Q9BVS5 TRMT61B  1 0.615 3
 IntAct:EBI-10198008 7120      0.556 3
 IntAct:EBI-10197995 7116      0.556 3
 UniProt:Q5W5X9 TTC23      0.556 3
 UniProt:Q15560 TCEA2      0.556 3
 UniProt:Q8TD31-3 CCHCR1      0.556 3
 UniProt:Q7Z614 SNX20      0.556 3
 UniProt:P53829 CAF40      0.556 3
 UniProt:A8MXD5 GRXCR1  1 0.556 3
 UniProt:Q9NWW7 CB042      0.556 3
 UniProt:C9JCN9 HSBPL      0.556 3
 UniProt:Q9UMF0 ICAM5  1 0.556 3
 UniProt:P08579 SNRPB2  1 0.556 3
 UniProt:O75564-2 O755642      0.556 3
 UniProt:P48837  1 0.556 3
 UniProt:Q4G0R1 Q4G0R1      0.556 3
 UniProt:Q9NVN8 GNL3L      0.556 3
 UniProt:P40123 CAP2  1 0.556 3
 UniProt:Q68DK2-5 ZFYVE26      0.556 3
 UniProt:P32902  1 0.556 3
 UniProt:Q5TAP6 UTP14C  1 0.556 3
 UniProt:O14645 IDLC      0.556 3
 UniProt:Q6P444 MTFR2      0.556 5
 IntAct:EBI-10192162 7115      0.556 3
 UniProt:Q96CD0 FBXL8  1 0.556 3
 UniProt:Q02821  2 0.556 3
 UniProt:Q9Y2K6 USP20  1 0.556 3
 UniProt:O43516 WIPF1  1 0.556 3
 UniProt:Q8TCT0 CERK  1 0.556 3
 UniProt:Q765P7 MTSS2      0.556 3
 IntAct:EBI-10198019 84460      0.556 3
 UniProt:O75128 COBL      0.556 3
 UniProt:Q4VC05 BCL7A  1 0.556 3
 UniProt:Q9H788 SH24A      0.556 3
 UniProt:Q96CN5 LRC45      0.556 3
 UniProt:A0A0A0MR80 A0A0A0MR80      0.556 3
 IntAct:EBI-22620261 CCSB ORF ID      0.556 3
 UniProt:Q0P5Q0 Q0P5Q0      0.556 3
 UniProt:P40099  1 0.556 3
 UniProt:Q9HAQ2 KIF9  1 0.556 3
 UniProt:Q8IYW5 RNF168  2 0.556 3
 UniProt:Q9NZQ9 TMOD4  1 0.527 2
 UniProt:Q5BKU9 OXLD1      0.527 2
 UniProt:O75380 NDUFS6  1 0.527 4
 UniProt:Q5T1C6 THEM4  3 0.527 2
 UniProt:Q9NYL9 TMOD3  1 0.527 2
 UniProt:Q8IVS2 MCAT  1 0.527 3
 UniProt:Q16822 PCK2  1 0.527 2
 UniProt:P14324 FDPS  1 0.527 2
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