Reactome | CERK [plasma membrane]

CERK [plasma membrane]

Stable Identifier

R-HSA-1631584

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Ceramide kinase, CERK1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8TCT0 CERK

Gene Names

CERK, KIAA1646

Chain

chain:1-537

Reference Genes

BioGPS Gene:64781 CERK

COSMIC (genes):CERK CERK

CTD Gene:64781 CERK

dbSNP Gene:64781 CERK

ENSEMBL:ENSG00000100422 CERK

HGNC:19256 CERK

KEGG:hsa:64781 CERK

Monarch:64781 CERK

NCBI Gene:64781 CERK

OMIM:610307 CERK

UCSC:Q8TCT0 CERK

Reference Transcript

RefSeq:NM_022766.5 CERK

Other Identifiers

11717115_at

11717116_at

11750997_a_at

16936137

218421_PM_at

218421_at

3964156

3964157

3964158

3964159

3964160

3964161

3964162

3964163

3964164

3964165

3964166

3964168

3964170

3964171

3964172

3964173

3964174

3964178

3964179

3964184

3964185

3964186

3964187

3964188

51239_at

59011_at

64781

8076792

A_23_P211659

A_24_P62237

GE56762

GE633627

GE85505

GO:0000287

GO:0001729

GO:0003824

GO:0005515

GO:0005524

GO:0005737

GO:0005886

GO:0006629

GO:0006672

GO:0006688

GO:0016020

GO:0016301

GO:0016740

GO:0102773

GO:1901135

HMNXSV003018316

ILMN_1721325

ILMN_1767475

ILMN_2388975

PH_hs_0002840

TC22000890.hg

TC22001398.hg

g12232440_3p_at

Inferred To

Cerk [plasma membrane] (Drosophila melanogaster)

Cerk [plasma membrane] (Rattus norvegicus)

cerk [plasma membrane] (Xenopus tropicalis)

CERK [plasma membrane] (Bos taurus)

CERK [plasma membrane] (Caenorhabditis elegans)

CERK [plasma membrane] (Canis familiaris)

CERK [plasma membrane] (Gallus gallus)

CERK [plasma membrane] (Mus musculus)

CERK [plasma membrane] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

2473

OpenTargets

ENSG00000100422

ENSEMBL

ENSG00000100422, ENSP00000216264, ENST00000216264

HPA

ENSG00000100422-CERK

GeneCards

CERK

ZINC - Substances

CERK1_HUMAN

ZINC target

Q8TCT0

PRO

Q8TCT0

Pharos - Targets

Q8TCT0

HMDB Protein

HMDBP01405

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:P13196 ALAS1	2	PXLP-ALAS1 [mitochondrial matrix] (R-HSA-1022086) ALAS1 [mitochondrial matrix] (R-HSA-189438)	0.556	3
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.556	3
UniProt:Q9BYQ4 KRTAP9-2	1	KRTAP9-2 [cytosol] (R-HSA-6809965)	0.556	3
UniProt:P05813 CRBA1			0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:Q8IUB9 KRTAP19-1	1	KRTAP19-1 [cytosol] (R-HSA-6810285)	0.556	3
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:Q9BYR8 KRTAP3-1	1	KRTAP3-1 [cytosol] (R-HSA-6809868)	0.556	3
UniProt:Q3LI70 KRTAP19-6	1	KRTAP19-6 [cytosol] (R-HSA-6810286)	0.556	3
UniProt:P0CG21 NHLC4			0.556	3
UniProt:Q9BYR7 KRTAP3-2	1	KRTAP3-2 [cytosol] (R-HSA-6809857)	0.556	3
UniProt:Q8IWZ5 TRI42			0.556	3
UniProt:Q8IUC1 KRTAP11-1	1	KRTAP11-1 [cytosol] (R-HSA-6810294)	0.556	3
UniProt:Q3LI66 KRTAP6-2	1	KRTAP6-2 [cytosol] (R-HSA-6810261)	0.556	3
UniProt:O75496 GMNN	2	GMNN [nucleoplasm] (R-HSA-113554) PolyUb-GMNN [nucleoplasm] (R-HSA-68585)	0.527	2
UniProt:Q9UHF4 IL20RA	1	IL20RA [plasma membrane] (R-HSA-448713)	0.527	2
UniProt:Q07011 TNFRSF9	1	TNFRSF9 [plasma membrane] (R-HSA-5666996)	0.527	2
UniProt:Q01151 CD83			0.527	2
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.527	2
UniProt:Q96G30 MRAP2			0.527	2
UniProt:Q96DN2 VWCE			0.527	2
UniProt:Q8NHX9 TPCN2	1	TPCN2 [lysosomal membrane] (R-HSA-2685518)	0.527	2
UniProt:O95273 CCDB1			0.527	3

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