Reactome | PCK2 [mitochondrial matrix]

PCK2 [mitochondrial matrix]

Stable Identifier

R-HSA-372815

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Phosphoenolpyruvate carboxykinase (GTP), mitochondrial

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q16822 PCK2

Gene Names

PCK2, PEPCK2

Chain

transit peptide:1-32, chain:33-640

Reference Genes

BioGPS Gene:5106 PCK2

COSMIC (genes):PCK2 PCK2

CTD Gene:5106 PCK2

dbSNP Gene:5106 PCK2

ENSEMBL:ENSG00000100889 PCK2

HGNC:8725 PCK2

KEGG:hsa:5106 PCK2

Monarch:5106 PCK2

NCBI Gene:5106 PCK2

OMIM:614095 PCK2

UCSC:Q16822 PCK2

Reference Transcript

Other Identifiers

11719089_a_at

11728867_a_at

16782548

202847_PM_at

202847_at

3529509

3529510

3529511

3529512

3529513

3529514

3529515

3529517

3529518

3529519

3529520

3529521

3529522

3529523

3529524

3529525

3529526

3529527

3529528

3529529

3529530

3529531

3529532

3529533

3529534

3529535

3529536

3529537

3529538

3529539

3529541

3529542

3529543

3529544

3529545

3529546

37188_at

48623_at

5106

7973530

86118_at

A_14_P115524

A_23_P128817

A_23_P140207

A_33_P3268532

GE60154

GE656189

GE85050

GE85052

GO:0003824

GO:0004611

GO:0004613

GO:0005515

GO:0005525

GO:0005739

GO:0005759

GO:0005975

GO:0006090

GO:0006094

GO:0006107

GO:0006116

GO:0006629

GO:0016301

GO:0016740

GO:0016829

GO:0016831

GO:0017076

GO:0019543

GO:0030145

GO:0030154

GO:0032024

GO:0032496

GO:0032869

GO:0042594

GO:0043226

GO:0046327

GO:0046872

GO:0055086

GO:0070365

GO:0071333

GO:0071356

GO:0071548

GO:0071549

HMNXSV003014613

HMNXSV003043724

ILMN_1671791

ILMN_1760649

ILMN_1802699

PH_hs_0004373

TC14000157.hg

X92720_at

g4758885_3p_at

Inferred To

pck-2 [mitochondrial matrix] (Caenorhabditis elegans)

PCK2 [mitochondrial matrix] (Bos taurus)

PCK2 [mitochondrial matrix] (Canis familiaris)

PCK2 [mitochondrial matrix] (Dictyostelium discoideum)

PCK2 [mitochondrial matrix] (Drosophila melanogaster)

PCK2 [mitochondrial matrix] (Gallus gallus)

PCK2 [mitochondrial matrix] (Mus musculus)

PCK2 [mitochondrial matrix] (Sus scrofa)

pck2 [mitochondrial matrix] (Danio rerio)

Pck2 [mitochondrial matrix] (Rattus norvegicus)

Cross References

RefSeq

NP_001278485.1, NP_001294983.1, NP_001018083.2, NP_004554.3

OpenTargets

ENSG00000100889

ENSEMBL

ENST00000396973, ENST00000561286, ENSP00000216780, ENST00000216780, ENSG00000100889, ENST00000545054, ENSP00000496102, ENSP00000441826, ENSP00000454011, ENSP00000496343, ENSG00000285241, ENST00000645709, ENST00000644679, ENSP00000380171, ENSP00000494029, ENST00000645217, ENSP00000494919, ENST00000645536

IntEnz

4.1.1.32

HPA

ENSG00000100889-PCK2

GeneCards

PCK2

PRO

Q16822

Pharos - Targets

Q16822

GlyGen

Q16822

Orphanet

PCK2

HMDB Protein

HMDBP00890

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75380 NDUFS6	1	NDUFS6 [mitochondrial inner membrane] (R-HSA-163922)	0.527	2
UniProt:Q9UMX1 SUFU	3	SUFU [ciliary base] (R-HSA-5610424) SUFU [cytosol] (R-HSA-445455) SUFU [ciliary tip] (R-HSA-5610426)	0.527	3
UniProt:P01876 IGHA1	1	IGHA1 [extracellular region] (R-HSA-1478809)	0.527	2
UniProt:P01877 IGHA2	1	IGHA2 [extracellular region] (R-HSA-1478812)	0.527	2
UniProt:P13196 ALAS1	2	PXLP-ALAS1 [mitochondrial matrix] (R-HSA-1022086) ALAS1 [mitochondrial matrix] (R-HSA-189438)	0.527	2
UniProt:Q9HC84 MUC5B	18	GalNAc-MUC5B(26-5703) [plasma membrane] (R-HSA-8858460) Core 2 (MUC5B) [Golgi lumen] (R-HSA-1462273) Core 2a (MUC5B) [Golgi lumen] (R-HSA-6784272) GalNAc-MUC5B(26-5703) [Golgi lumen] (R-HSA-1463435) Sialyl Tn antigen (MUC5B) [Golgi lumen] (R-HSA-1463478) T-antigen (MUC5B) [Golgi lumen] (R-HSA-1462213) Sialyl-2,3 T-antigen (MUC5B) [Golgi lumen] (R-HSA-1463597) Sialyl T-antigen (MUC5B) [Golgi lumen] (R-HSA-1463481) Disialyl T-antigen (MUC5B) [Golgi lumen] (R-HSA-1463459) MUC5B(26-5703) [Golgi lumen] (R-HSA-913676) Core 6 (MUC5B) [Golgi lumen] (R-HSA-1462242) extended Core 6 (MUC5B) [Golgi lumen] (R-HSA-1967031) Core 7 (MUC5B) [Golgi lumen] (R-HSA-1462327) Core 3 (MUC5B) [Golgi lumen] (R-HSA-1462201) Core 4 (MUC5B) [Golgi lumen] (R-HSA-1462291) Core 5 (MUC5B) [Golgi lumen] (R-HSA-1462075) Core 2S (MUC5B) [Golgi lumen] (R-HSA-6786324) Core 8 (MUC5B) [Golgi lumen] (R-HSA-1462102)	0.527	2
UniProt:Q9NP55 BPIFA1	1	BPIFA1 [extracellular region] (R-HSA-6809280)	0.527	2
UniProt:Q8TDL5 BPIFB1	1	BPIFB1 [extracellular region] (R-HSA-6809282)	0.527	2
UniProt:P35558 PCK1	1	PCK1 [cytosol] (R-HSA-70495)	0.527	2
UniProt:Q9GZZ8 LACRT			0.527	2
UniProt:Q96DA0 PAUF			0.527	2
UniProt:P17677 GAP43	2	GAP43 [plasma membrane] (R-HSA-452888) PALM-C3,4-GAP43 [plasma membrane] (R-HSA-8933482)	0.527	2
UniProt:Q9UBW7 ZMYM2	6	ZMYM2(1-1057)-FLT3(586-993) fusion [cytosol] (R-HSA-9703311) ZMYM2(1-1059)-FLT3(594-993) fusion [cytosol] (R-HSA-9703310) ZMYM2(1-1057)-p-5Y-FLT3(586-993) fusion [cytosol] (R-HSA-9703319) ZMYM2(1-1059)-p-4Y-FLT3(594-993) fusion [cytosol] (R-HSA-9703309) ZMYM2(1-913)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604544) ZMYM2(1-913)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839016)	0.527	3
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.508	2
UniProt:Q9BXC9 BBS2	1	BBS2 [cytosol] (R-HSA-5617637)	0.508	2
UniProt:P10809 HSPD1	6	HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.483	2

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