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Table of Contents
DOIs
Data Schema
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Computational inferred events
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FDPS [cytosol]
Stable Identifier
R-HSA-981566
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
farnesyl diphosphate synthase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Cholesterol biosynthesis (Homo sapiens)
Addition of isopentenyl pyrophosphate to DMAPP (Homo sapiens)
FDPS,GGPS1 [cytosol] (Homo sapiens)
2(FDPS:3Mg2+) [cytosol] (Homo sapiens)
FDPS:3Mg2+ [cytosol] (Homo sapiens)
FDPS [cytosol] (Homo sapiens)
Another isopentenyl pyrophosphate is added to geranyl pyrophosphate (Homo sapiens)
FDPS,GGPS1 [cytosol] (Homo sapiens)
2(FDPS:3Mg2+) [cytosol] (Homo sapiens)
FDPS:3Mg2+ [cytosol] (Homo sapiens)
FDPS [cytosol] (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of Farnesyl Diphosphate Synthase (FDPS) (Homo sapiens)
FDPS [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14324 FDPS
Gene Names
FDPS, FPS, KIAA1293
Chain
chain:1-419
Reference Genes
BioGPS Gene:2224 FDPS
COSMIC (genes):FDPS FDPS
CTD Gene:2224 FDPS
dbSNP Gene:2224 FDPS
ENSEMBL:ENSG00000160752 FDPS
ENSEMBL_homo_sapiens_GENE:ENSG00000160752 FDPS
HGNC:3631 FDPS
KEGG Gene (Homo sapiens):2224 FDPS
Monarch:2224 FDPS
NCBI Gene:2224 FDPS
OMIM:134629 FDPS
UCSC:P14324 FDPS
Reference Transcript
RefSeq:NM_001135822.1 FDPS
RefSeq:XM_005244963.1 FDPS
RefSeq:NM_001242824.1 FDPS
RefSeq:NM_002004.3 FDPS
RefSeq:NM_001135821.1 FDPS
RefSeq:NM_001242825.1 FDPS
RefSeq:XM_005244962.1 FDPS
Other Identifiers
0000130731
11718366_s_at
11758249_s_at
16671738
1YQ7
1YV5
1ZW5
201275_at
2224
2360852
2360853
2360856
2360858
2360860
2360861
2360862
2360864
2360865
2360866
2360869
2360871
2360872
2360875
2360876
2360878
2360879
2360880
2360888
28200
2F7M
2F89
2F8C
2F8Z
2F92
2F94
2F9K
2OPM
2OPN
2QIS
2RAH
2VF6
37325_at
3B7L
3CP6
3N1V
3N1W
3N3L
3N45
3N46
3N49
3N5H
3N5J
3N6K
3RYE
3S4J
4006403
4DEM
4GA3
4H5C
4H5D
4H5E
4JVJ
4KFA
4KPD
4KPJ
4KQ5
4KQS
4KQU
4L2X
4LFV
4LPG
4LPH
4N1Z
4N9U
4NFI
4NFJ
4NFK
4NG6
4NKE
4NKF
4NUA
4OGU
4P0V
4P0W
4P0X
4PVX
4PVY
4Q23
4QPF
4QXS
4RXA
4XQR
4XQS
4XQT
5CG5
5CG6
5DGM
5DGN
5DGS
5DIQ
5DJP
5DJR
5DJV
5JA0
5JUZ
5JV0
5JV1
5JV2
5KSX
7905986
A0A087WTP2
A0A087WVN4
A0A087X090
A0A087X1D8
A_14_P200040
A_24_P114183
AAA35820
AAA52423
AAH10004
BAA03523
BAF83773
CCDS1110
CCDS44241
EAW53076
EAW53077
EAW53078
ENSG00000160752
ENSP00000349078
ENSP00000357340
ENSP00000391755
ENSP00000478235
ENSP00000480142
ENST00000356657
ENST00000368356
ENST00000447866
ENST00000467076
ENST00000612683
EntrezGene:2224
FDPS
FDPS-201
FDPS-202
FDPS-203
FDPS-206
FDPS-221
g4503684_3p_at
g4503684_3p_x_at
GE79405
GO:0003674
GO:0003723
GO:0004161
GO:0004337
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006629
GO:0006694
GO:0006695
GO:0008150
GO:0008202
GO:0008203
GO:0008299
GO:0009058
GO:0016032
GO:0016126
GO:0016740
GO:0016765
GO:0033384
GO:0043167
GO:0043226
GO:0044281
GO:0044403
GO:0045337
GO:0045540
GO:0046872
HGNC:3631
HPA028200
ILMN_1804248
IPR000092
IPR008949
IPR033749
MIM:134629
MIM:616631
NM_001135821
NM_001135822
NM_001242824
NM_002004
NP_001129293
NP_001129294
NP_001229753
NP_001995
PF00348
uc001fkc.3
uc001fkd.3
uc001fke.3
uc021paw.2
uc057lpq.1
UPI000006E4F7
UPI000012ABB5
XM_005244962
XM_005244963
XP_005245019
XP_005245020
Z47055_s_at
Participant Of
output
Expression of Farnesyl Diphosphate Synthase (FDPS)
hasComponent
FDPS:3Mg2+ [cytosol]
Inferred To
FDPS [cytosol] (Arabidopsis thaliana)
FDPS [cytosol] (Bos taurus)
FDPS [cytosol] (Caenorhabditis elegans)
FDPS [cytosol] (Canis familiaris)
FDPS [cytosol] (Danio rerio)
FDPS [cytosol] (Dictyostelium discoideum)
FDPS [cytosol] (Drosophila melanogaster)
FDPS [cytosol] (Gallus gallus)
FDPS [cytosol] (Mus musculus)
FDPS [cytosol] (Oryza sativa)
FDPS [cytosol] (Plasmodium falciparum)
FDPS [cytosol] (Saccharomyces cerevisiae)
FDPS [cytosol] (Schizosaccharomyces pombe)
FDPS [cytosol] (Sus scrofa)
Homologues of FDPS [cytosol] (Arabidopsis thaliana)
Homologues of FDPS [cytosol] (Danio rerio)
Homologues of FDPS [cytosol] (Dictyostelium discoideum)
Homologues of FDPS [cytosol] (Drosophila melanogaster)
Homologues of FDPS [cytosol] (Gallus gallus)
Homologues of FDPS [cytosol] (Oryza sativa)
Homologues of FDPS [cytosol] (Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001995.1
,
NP_001129293.1
,
XP_005245020.1
,
NP_001229754.1
,
XP_005245019.1
,
NP_001129294.1
,
NP_001229753.1
ZINC - World Drugs
FPPS_HUMAN
OpenTargets
ENSG00000160752
ZINC - FDA approved
FPPS_HUMAN
ZINC - Substances
FPPS_HUMAN
ZINC target
P14324
ZINC - Biogenic
FPPS_HUMAN
PRO
P14324
PDB
4DEM
,
4QXS
,
4KFA
,
3N1W
,
3RYE
,
4XQR
,
2F89
,
4LFV
,
4KQS
,
4XQS
,
5DIQ
,
4KQU
,
1YV5
,
4PVX
,
4QPF
,
2F8C
,
3N1V
,
4PVY
,
2VF6
,
4NFI
,
4H5E
,
5JV0
,
4NFJ
,
2F94
,
4N9U
,
3B7L
,
5JA0
,
3N5H
,
4XQT
,
2F8Z
,
4H5C
,
4N1Z
,
2QIS
,
4NUA
,
2F92
,
4H5D
,
3N5J
,
4L2X
,
4KPD
,
5DJV
,
4P0W
,
3N6K
,
4LPH
,
4P0V
,
4NG6
,
5DGS
,
3CP6
,
3N45
,
5DGM
,
4GA3
,
4NFK
,
5JUZ
,
5DJP
,
2F9K
,
4JVJ
,
4LPG
,
5DGN
,
4RXA
,
5JV2
,
4Q23
,
4OGU
,
3N3L
,
5DJR
,
5JV1
,
3N49
,
4KQ5
,
1ZW5
,
1YQ7
,
5YGI
,
4KPJ
,
3N46
,
2OPN
,
5CG6
,
5CG5
,
3S4J
,
4P0X
,
2OPM
,
2RAH
,
4NKF
,
5KSX
,
2F7M
,
4NKE
ZINC - Metabolites
FPPS_HUMAN
GeneCards
P14324
DOCK Blaster
2F92
,
4NG6
,
2F89
,
3B7L
,
3N3L
,
3N45
,
2F8Z
,
4LFV
,
4P0W
,
4XQR
,
5JA0
,
4XQS
,
3N5H
,
4NUA
,
2F8C
,
4GA3
,
1ZW5
,
2F7M
,
5JV2
,
2F9K
,
4H5E
,
2OPM
,
4DEM
,
2OPN
,
4H5C
,
4JVJ
,
1YQ7
,
3N1V
,
4KQU
,
4LPG
,
4KQS
,
4NFJ
,
4QXS
,
4NKE
,
4N1Z
,
4L2X
,
4OGU
,
2F94
,
5DGS
,
4P0V
,
3RYE
,
5DGN
,
3N49
,
3N46
,
5DGM
,
5JUZ
,
4PVX
,
5JV0
,
4P0X
,
4N9U
,
5KSX
,
1YV5
,
5JV1
,
5DJV
,
2VF6
,
2QIS
,
5DJP
,
4KFA
,
4NFK
,
3CP6
,
4QPF
,
4H5D
,
4PVY
,
4KQ5
,
5DIQ
,
3N5J
,
4Q23
,
4XQT
,
4RXA
,
3S4J
,
2RAH
,
4NFI
,
3N1W
,
3N6K
,
4LPH
,
5DJR
,
4NKF
,
4KPJ
,
4KPD
BRENDA (Homo sapiens)
2.5.1.10
,
2.5.1.1
ZINC - Predictions - Purchasable
FPPS_HUMAN
Orphanet
23495
HMDB Protein
HMDBP00932
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6ZMZ0 RNF19B
1
RNF19B [cytosol]
(R-HSA-975969)
0.488
2
UniProt:Q8WWF3 SSMM1
0.488
2
UniProt:O95870 ABHGA
0.488
2
UniProt:Q9NRA8 4ET
0.488
2
UniProt:Q9BRI3 SLC30A2
2
SLC30A2 [synaptic vesicle membrane]
(R-HSA-4084714)
SLC30A2 [endosome membrane]
(R-HSA-435363)
0.488
2
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