Reactome | FDPS [cytosol]

FDPS [cytosol]

Stable Identifier

R-HSA-981566

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

farnesyl diphosphate synthase

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P14324 FDPS

Gene Names

FDPS, FPS, KIAA1293

Chain

chain:1-419

Reference Genes

BioGPS Gene:2224 FDPS

COSMIC (genes):FDPS FDPS

CTD Gene:2224 FDPS

dbSNP Gene:2224 FDPS

ENSEMBL:ENSG00000160752 FDPS

HGNC:3631 FDPS

KEGG:hsa:2224 FDPS

Monarch:2224 FDPS

NCBI Gene:2224 FDPS

OMIM:134629 FDPS

UCSC:P14324 FDPS

Reference Transcript

Other Identifiers

11718366_s_at

11758249_s_at

16671738

201275_PM_at

201275_at

2224

2360852

2360853

2360854

2360855

2360856

2360857

2360858

2360859

2360860

2360861

2360862

2360863

2360864

2360865

2360866

2360867

2360868

2360869

2360870

2360871

2360872

2360873

2360874

2360875

2360876

2360877

2360878

2360879

2360880

2360888

2360889

37325_at

4006403

7905986

A_14_P118865

A_14_P200040

A_24_P114183

GE79405

GO:0003723

GO:0003824

GO:0004161

GO:0004337

GO:0004659

GO:0005515

GO:0005654

GO:0005737

GO:0005759

GO:0005777

GO:0005829

GO:0006629

GO:0006695

GO:0008299

GO:0016020

GO:0016740

GO:0016765

GO:0033384

GO:0043226

GO:0045337

GO:0046872

HMNXSV003028031

ILMN_1804248

PH_hs_0038496

TC01001299.hg

Z47055_s_at

g4503684_3p_at

g4503684_3p_x_at

Participates

as an output of

Expression of Farnesyl Diphosphate Synthase (FDPS) (Homo sapiens)

as a component of

FDPS:3Mg2+ [cytosol] (Homo sapiens)

Inferred To

FDPS [cytosol] (Canis familiaris)

FDPS [cytosol] (Dictyostelium discoideum)

FDPS [cytosol] (Gallus gallus)

FDPS [cytosol] (Mus musculus)

FDPS [cytosol] (Plasmodium falciparum)

FDPS [cytosol] (Rattus norvegicus)

FDPS [cytosol] (Saccharomyces cerevisiae)

FDPS [cytosol] (Schizosaccharomyces pombe)

FDPS [cytosol] (Sus scrofa)

fdps [cytosol] (Danio rerio)

fdps-1 [cytosol] (Caenorhabditis elegans)

Fpps [cytosol] (Drosophila melanogaster)

Cross References

ZINC - World Drugs

FPPS_HUMAN

Guide to Pharmacology - Targets

644

OpenTargets

ENSG00000160752

ENSEMBL

ENST00000467076, ENST00000356657, ENSP00000391755, ENST00000447866, ENST00000612683, ENSP00000480142, ENSP00000349078, ENSP00000357340, ENSP00000478235, ENST00000368356

ZINC - FDA approved

FPPS_HUMAN

ZINC - Substances

FPPS_HUMAN

ZINC - Biogenic

FPPS_HUMAN

ZINC target

P14324

PRO

P14324

GlyGen

P14324

PDB

2OPN, 5DIQ, 2OPM, 4Q23, 4LPG, 4RXA, 5KSX, 6OAG, 4LPH, 3N1W, 3N45, 2F9K, 5JV1, 5DJP, 4XQS, 3N3L, 5DGN, 4NFK, 3CP6, 4L2X, 5CG6, 2F8C, 4XQR, 4P0X, 4NUA, 2F94, 4NFJ, 4KQS, 6N82, 4P0W, 4NKE, 6N7Y, 4P0V, 3RYE, 6N83, 4OGU, 6N7Z, 4NG6, 6OAH, 4N1Z, 1YV5, 3N49, 2F89, 3S4J, 5JUZ, 5JV0, 2VF6, 5JA0, 4KFA, 3N6K, 5DJR, 2RAH, 5JV2, 3N46, 3N1V, 5DJV, 2F7M, 4XQT, 2QIS, 4DEM, 4N9U, 1YQ7, 5CG5, 4PVY, 5YGI, 5DGM, 4KPD, 4NFI, 4PVX, 4NKF, 4H5E, 4KQU, 4H5D, 4JVJ, 4KQ5, 2F92, 4QPF, 3N5H, 3B7L, 5DGS, 1ZW5, 4H5C, 4KPJ, 3N5J, 2F8Z, 4GA3, 4LFV, 4QXS

ZINC - Investigational

FPPS_HUMAN

ZINC - Metabolites

FPPS_HUMAN

IntEnz

2.5.1.1

HPA

ENSG00000160752-FDPS

Pharos - Targets

P14324

Orphanet

FDPS

ZINC - Predictions - Purchasable

FPPS_HUMAN

HMDB Protein

HMDBP00932

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54253 ATX1			0.666	4
UniProt:Q8WWF3 SSMM1			0.556	3
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.556	3
UniProt:O95870 ABHGA			0.556	3
UniProt:Q6ZMZ0 RNF19B	1	RNF19B [cytosol] (R-HSA-975969)	0.556	3
UniProt:Q6DKK2 TTC19	1	TTC19 [mitochondrial inner membrane] (R-HSA-9906047)	0.527	2
UniProt:Q14997 PSME4	1	PSME4 [cytosol] (R-HSA-947606)	0.527	2
UniProt:Q8N5M1 ATPF2			0.527	2
UniProt:P13196 ALAS1	2	PXLP-ALAS1 [mitochondrial matrix] (R-HSA-1022086) ALAS1 [mitochondrial matrix] (R-HSA-189438)	0.527	2
UniProt:Q5TEU4 NDUFAF5	1	NDUFAF5 [mitochondrial inner membrane] (R-HSA-5689127)	0.527	2
UniProt:P23378 GLDC	1	PXLP-K754-GLDC [mitochondrial matrix] (R-HSA-5693966)	0.527	2
UniProt:Q9UHG3 PCYOX			0.527	2
UniProt:O75844 FACE1			0.527	2
UniProt:Q86YH6 PDSS2	1	PDSS2 [mitochondrial matrix] (R-HSA-2162264)	0.527	2
UniProt:Q9NRA8 4ET			0.488	2