Reactome | PPL [cornified envelope]

PPL [cornified envelope]

Stable Identifier

R-HSA-8847709

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cornified envelope

Synonyms

Periplakin, PEPL_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Keratinization (Homo sapiens)
  - Formation of the cornified envelope (Homo sapiens)
    - Plasma membrane resorption (Homo sapiens)
      - Mature cornified envelope [cornified envelope] (Homo sapiens)
        
        No FGN-cornified envelope:CDSN [cornified envelope] (Homo sapiens)
        
        No FGN-Cornified envelope [cornified envelope] (Homo sapiens)
        
        No FGN-early cornified envelope [cornified envelope] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1 [cornified envelope] (Homo sapiens)
        
        EVPL:PPL [cornified envelope] (Homo sapiens)
        
        PPL [cornified envelope] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60437 PPL

Gene Names

PPL, KIAA0568

Chain

chain:1-1756

Reference Genes

BioGPS Gene:5493 PPL

COSMIC (genes):PPL PPL

CTD Gene:5493 PPL

dbSNP Gene:5493 PPL

ENSEMBL:ENSG00000118898 PPL

ENSEMBL_homo_sapiens_GENE:ENSG00000118898.16 PPL

HGNC:9273 PPL

KEGG Gene (Homo sapiens):5493 PPL

Monarch:5493 PPL

NCBI Gene:5493 PPL

OMIM:602871 PPL

UCSC:O60437 PPL

Reference Transcript

RefSeq:NM_002705.4 PPL

Other Identifiers

11722428_a_at

11722429_s_at

11722430_at

11750591_a_at

16823666

203407_PM_at

203407_at

3678463

3678464

3678465

3678466

3678467

3678468

3678469

3678470

3678472

3678474

3678475

3678479

3678480

3678483

3678484

3678485

3678486

3678487

3678488

3678490

3678491

3678492

3678493

3678494

3678496

3678497

3678508

3678509

36890_at

5493

7999253

A_23_P106906

GE54042

GO:0001533

GO:0005198

GO:0005200

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005856

GO:0005882

GO:0005886

GO:0007010

GO:0009612

GO:0016020

GO:0030057

GO:0030154

GO:0031424

GO:0042060

GO:0043226

GO:0045104

GO:0045296

GO:0048856

GO:0070062

GO:0070161

HMNXSV003049489

ILMN_1806030

PH_hs_0022926

TC16000838.hg

g4505992_3p_at

Participates

as a component of

EVPL:PPL [cornified envelope] (Homo sapiens)

Other forms of this molecule

PPL [cytosol]

Inferred To

Ppl [cornified envelope] (Mus musculus)

Ppl [cornified envelope] (Rattus norvegicus)

PPL [cornified envelope] (Bos taurus)

PPL [cornified envelope] (Canis familiaris)

PPL [cornified envelope] (Sus scrofa)

Cross References

RefSeq

NP_002696.3

OpenTargets

ENSG00000118898

GeneCards

O60437

HPA

ENSG00000118898-PPL

Ensembl

ENSP00000340510, ENST00000345988, ENSG00000118898

PRO

O60437

Pharos - Targets

O60437

PDB

4Q28

Interactors (46)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13196 ALAS1	2	PXLP-ALAS1 [mitochondrial matrix] (R-HSA-1022086) ALAS1 [mitochondrial matrix] (R-HSA-189438)	0.718	6
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.718	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	8
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.666	5
UniProt:O76027 ANXA9			0.664	7
UniProt:O00481 BTN3A1	1	BTN3A1 [plasma membrane] (R-HSA-8851049)	0.625	6
UniProt:Q6A163 KRT39	1	KRT39 [cytosol] (R-HSA-6809592)	0.601	4
UniProt:O00481-2 BTN3A1			0.591	5
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.573	2
UniProt:Q9H4T2 ZSC16			0.556	3
UniProt:Q13084 MRPL28	1	MRPL28 [mitochondrial inner membrane] (R-HSA-5368246)	0.556	3
UniProt:Q6S9Z5 ZN474			0.556	3
UniProt:Q8WVV4-1 POF1B			0.556	3
UniProt:Q5T447 HECTD3	1	HECTD3 [cytosol] (R-HSA-975991)	0.556	3
UniProt:Q6IQ23-2 PLEKHA7			0.556	3
UniProt:Q9BYU1 PBX4			0.556	3
UniProt:Q9Y3Q8 T22D4			0.556	3
UniProt:Q96QF0-7 RAB3IP			0.556	3
UniProt:O14771 ZNF213	1	ZNF213 [nucleoplasm] (R-HSA-1027351)	0.556	3
UniProt:Q8IYX8-2 CEP57L1			0.556	3
UniProt:Q9Y448 SKAP			0.556	3
UniProt:P17661 DES	1	DES [cytosol] (R-HSA-390570)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:O14978 ZNF263	1	ZNF263 [nucleoplasm] (R-HSA-1027393)	0.556	3
UniProt:Q96BW1 UPP			0.556	3
UniProt:Q9HCK0 ZBT26			0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.556	3
UniProt:Q96QF0 RAB3IP	1	RAB3IP [cytosol] (R-HSA-5617610)	0.556	3
UniProt:Q9H9F9 ACTR5	1	ACTR5 [nucleoplasm] (R-HSA-5688913)	0.556	3
UniProt:Q5SZD1 CF141			0.556	3
UniProt:Q8NBB4 ZSCA1			0.556	3
UniProt:Q7Z3Z0 KRT25	1	KRT25 [cytosol] (R-HSA-6809613)	0.556	3
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:O43865 AHCYL1	1	AHCYL1 [endoplasmic reticulum membrane] (R-HSA-5215973)	0.556	3
UniProt:P49910 ZN165			0.556	3
UniProt:Q8NBB4-2 ZSCAN1			0.556	3
UniProt:Q4G0X4 KCD21			0.556	3
UniProt:Q9HAW8 UGT1A10	1	UGT1A10 [endoplasmic reticulum membrane] (R-HSA-8933307)	0.527	2
UniProt:P02794 FTH1	5	FTH1 [ficolin-1-rich granule lumen] (R-HSA-6801531) FTH1 [tertiary granule lumen] (R-HSA-6801508) FTH1 [cytosol] (R-HSA-434212) FTH1 [endocytic vesicle lumen] (R-HSA-2299670) FTH1 [extracellular region] (R-HSA-2187212)	0.527	2
UniProt:Q8N878 FRMD1			0.527	2
UniProt:Q14943 KIR3DS1	1	KIR3DS1 [plasma membrane] (R-HSA-2159806)	0.527	2
UniProt:Q9NU19 TB22B			0.527	2
UniProt:Q9H845 ACAD9	1	ACAD9 [mitochondrial inner membrane] (R-HSA-5689049)	0.527	2
UniProt:Q9BX46 RBM24			0.527	2
UniProt:Q9Y324 FCF1	1	FCF1 [nucleoplasm] (R-HSA-6790672)	0.527	2

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