Reactome | ALAS1 [mitochondrial matrix]

ALAS1 [mitochondrial matrix]

Stable Identifier

R-HSA-189438

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

5-aminolevulinate synthase, non-specific, HEM1_HUMAN, 5-aminolevulinate synthase, non-specific, mitochondrial

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P13196 ALAS1

Gene Names

ALAS1, ALAS3, ALASH, OK/SW-cl.121

Chain

transit peptide:1-56, chain:57-640

Reference Genes

BioGPS Gene:211 ALAS1

COSMIC (genes):ALAS1 ALAS1

CTD Gene:211 ALAS1

dbSNP Gene:211 ALAS1

ENSEMBL:ENSG00000023330 ALAS1

HGNC:396 ALAS1

KEGG:hsa:211 ALAS1

Monarch:211 ALAS1

NCBI Gene:211 ALAS1

OMIM:125290 ALAS1

UCSC:P13196 ALAS1

Reference Transcript

Other Identifiers

11719328_a_at

11719329_x_at

11733041_a_at

11750973_a_at

16941344

205633_PM_s_at

205633_s_at

211

2623526

2623527

2623529

2623530

2623532

2623535

2623537

2623538

2623539

2623540

2623541

2623542

2623543

2623545

2623546

2623547

2623548

2623549

2623550

2623551

2623552

2623553

2623555

2623556

37674_at

8080184

A_23_P57877

A_24_P191588

GE59815

GE60231

GO:0003824

GO:0003870

GO:0005515

GO:0005654

GO:0005739

GO:0005743

GO:0005759

GO:0005829

GO:0006778

GO:0006782

GO:0006783

GO:0006784

GO:0006785

GO:0009058

GO:0016020

GO:0016740

GO:0016746

GO:0030170

GO:0033014

GO:0042541

GO:0042802

GO:0043226

GO:0048034

GO:0048821

GO:0048856

GO:1903412

HMNXSV003050344

ILMN_1700047

ILMN_1728309

ILMN_2385647

PH_hs_0026670

PH_hs_0031344

TC03000329.hg

Y00451_s_at

g4502024_3p_a_at

Participates

as a component of

ALAS1:heme [mitochondrial matrix] (Homo sapiens)

as an output of

Expression of ALAS1 (Homo sapiens)

Other forms of this molecule

PXLP-ALAS1 [mitochondrial matrix]

Inferred To

Alas [mitochondrial matrix] (Drosophila melanogaster)

alas1 [mitochondrial matrix] (Xenopus tropicalis)

ALAS1 [mitochondrial matrix] (Bos taurus)

ALAS1 [mitochondrial matrix] (Canis familiaris)

ALAS1 [mitochondrial matrix] (Mus musculus)

ALAS1 [mitochondrial matrix] (Rattus norvegicus)

ALAS1 [mitochondrial matrix] (Sus scrofa)

Cross References

OpenTargets

ENSG00000023330

ENSEMBL

ENSP00000417719, ENSP00000378416, ENST00000394965, ENST00000484952, ENSP00000309259, ENSP00000418779, ENST00000469224, ENST00000310271

IntEnz

2.3.1.37

HPA

ENSG00000023330-ALAS1

PRO

P13196

Pharos - Targets

P13196

Orphanet

ALAS1

HMDB Protein

HMDBP00022

Interactors (62)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WTR2 DUS19			0.871	9
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.781	9
UniProt:O60437 PPL	2	PPL [cytosol] (R-HSA-6810850) PPL [cornified envelope] (R-HSA-8847709)	0.718	6
UniProt:Q9Y473 ZNF175	1	ZNF175 [nucleoplasm] (R-HSA-975022)	0.718	6
UniProt:Q8WW24 TEKT4			0.718	6
UniProt:Q8TBZ8 ZNF564	1	ZNF564 [nucleoplasm] (R-HSA-1973885)	0.718	6
UniProt:Q17RB0 RTL8B			0.718	6
UniProt:Q17RB8 LONRF1	1	LONRF1 [cytosol] (R-HSA-8850905)	0.718	6
UniProt:P63313 TYB10			0.718	6
UniProt:Q6PF15 KLH35			0.675	4
UniProt:Q96L91 EP400	1	EP400 [nucleoplasm] (R-HSA-3321987)	0.666	4
UniProt:P13196 ALAS1	2	PXLP-ALAS1 [mitochondrial matrix] (R-HSA-1022086) ALAS1 [mitochondrial matrix] (R-HSA-189438)	0.666	4
UniProt:Q9Y2S7 PDIP2			0.666	4
UniProt:Q9BVS5 TRMT61B	1	TRMT61B [mitochondrial matrix] (R-HSA-6787512)	0.615	3
IntAct:EBI-10198008 7120			0.556	3
IntAct:EBI-10197995 7116			0.556	3
UniProt:Q5W5X9 TTC23			0.556	3
UniProt:Q15560 TCEA2			0.556	3
UniProt:Q8TD31-3 CCHCR1			0.556	3
UniProt:Q7Z614 SNX20			0.556	3
UniProt:P53829 CAF40			0.556	3
UniProt:A8MXD5 GRXCR1	1	GRXCR1 [cytosol] (R-HSA-9663063)	0.556	3
UniProt:Q9NWW7 CB042			0.556	3
UniProt:C9JCN9 HSBPL			0.556	3
UniProt:Q9UMF0 ICAM5	1	ICAM5 [plasma membrane] (R-HSA-197684)	0.556	3
UniProt:P08579 SNRPB2	1	SNRPB2 [nucleoplasm] (R-HSA-71960)	0.556	3
UniProt:O75564-2 O755642			0.556	3
UniProt:P48837	1	NUP57 [nuclear envelope] (R-SCE-157724)	0.556	3
UniProt:Q4G0R1 Q4G0R1			0.556	3
UniProt:Q9NVN8 GNL3L			0.556	3
UniProt:Q9HAQ2 KIF9	1	KIF9 [cytosol] (R-HSA-984616)	0.556	3
UniProt:Q8TCT0 CERK	1	CERK [plasma membrane] (R-HSA-1631584)	0.556	3
UniProt:Q8IYW5 RNF168	2	RNF168 [nucleoplasm] (R-HSA-4551605) monoSUMO1-RNF168 [nucleoplasm] (R-HSA-4551750)	0.556	3
UniProt:P40099	1	MTHFS [cytosol] (R-SCE-6801331)	0.556	3
UniProt:Q0P5Q0 Q0P5Q0			0.556	3
IntAct:EBI-22620261 CCSB ORF ID			0.556	3
UniProt:A0A0A0MR80 A0A0A0MR80			0.556	3
UniProt:Q96CN5 LRC45			0.556	3
UniProt:Q9H788 SH24A			0.556	3
UniProt:Q4VC05 BCL7A	1	BCL7A [nucleoplasm] (R-HSA-9727449)	0.556	3
UniProt:O75128 COBL			0.556	3
IntAct:EBI-10198019 84460			0.556	3
UniProt:Q765P7 MTSS2			0.556	3
UniProt:O43516 WIPF1	1	WIPF1 [cytosol] (R-HSA-201874)	0.556	3
UniProt:Q9Y2K6 USP20	1	USP20 [cytosol] (R-HSA-5696946)	0.556	3
UniProt:Q02821	2	SRP1 [cytosol] (R-SCE-180612) SRP1 [cytosol] (R-SCE-9734672)	0.556	3
UniProt:Q96CD0 FBXL8	1	FBXL8 [cytosol] (R-HSA-8850912)	0.556	3
IntAct:EBI-10192162 7115			0.556	3
UniProt:Q6P444 MTFR2			0.556	5
UniProt:O14645 IDLC			0.556	3
UniProt:Q5TAP6 UTP14C	1	UTP14C [nucleoplasm] (R-HSA-8867818)	0.556	3
UniProt:P32902	1	MRP4 [mitochondrial matrix] (R-SCE-9839682)	0.556	3
UniProt:Q68DK2-5 ZFYVE26			0.556	3
UniProt:P40123 CAP2	1	CAP2 [cytosol] (R-HSA-428863)	0.556	3
UniProt:Q9NZQ9 TMOD4	1	TMOD4 [cytosol] (R-HSA-5694030)	0.527	2
UniProt:Q5BKU9 OXLD1			0.527	2
UniProt:Q5T1C6 THEM4	3	THEM4 [mitochondrial matrix] (R-HSA-162408) THEM4 [cytosol] (R-HSA-6809345) THEM4 [plasma membrane] (R-HSA-199437)	0.527	2
UniProt:Q9NYL9 TMOD3	1	TMOD3 [cytosol] (R-HSA-217354)	0.527	2
UniProt:P14324 FDPS	1	FDPS [cytosol] (R-HSA-981566)	0.527	2
UniProt:Q8IVS2 MCAT	1	MCAT [mitochondrial matrix] (R-HSA-8933305)	0.527	3
UniProt:O75380 NDUFS6	1	NDUFS6 [mitochondrial inner membrane] (R-HSA-163922)	0.527	4
UniProt:Q16822 PCK2	1	PCK2 [mitochondrial matrix] (R-HSA-372815)	0.527	2

Cite Us!