Reactome | USP20 [cytosol]

USP20 [cytosol]

Stable Identifier

R-HSA-5696946

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin carboxyl-terminal hydrolase 20 ecNumber3.4.19.12/ecNumber, UBP20_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y2K6 USP20

Gene Names

USP20, KIAA1003, LSFR3A, VDU2

Chain

chain:1-914

Reference Genes

BioGPS Gene:10868 USP20

COSMIC (genes):USP20 USP20

CTD Gene:10868 USP20

dbSNP Gene:10868 USP20

ENSEMBL:ENSG00000136878 USP20

ENSEMBL_homo_sapiens_GENE:ENSG00000136878.14 USP20

HGNC:12619 USP20

KEGG Gene (Homo sapiens):10868 USP20

Monarch:10868 USP20

NCBI Gene:10868 USP20

OMIM:615143 USP20

UCSC:Q9Y2K6 USP20

Reference Transcript

Other Identifiers

10868

11720891_a_at

17090121

203965_PM_at

203965_at

3191178

3191179

3191183

3191185

3191186

3191188

3191190

3191192

3191194

3191196

3191197

3191198

3191200

3191201

3191202

3191204

3191205

3191207

3191208

3191210

3191211

3191212

3191214

3191216

3191217

3191218

3191220

3191221

3191222

3191223

3191224

3191225

3191226

3191227

3191228

36473_at

8158568

A_23_P217028

GE53649

GO:0001664

GO:0002376

GO:0003824

GO:0004197

GO:0004843

GO:0005515

GO:0005737

GO:0005783

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006508

GO:0006807

GO:0006897

GO:0006914

GO:0008233

GO:0008234

GO:0008270

GO:0008277

GO:0010508

GO:0016192

GO:0016579

GO:0016787

GO:0023052

GO:0036211

GO:0043124

GO:0043170

GO:0043226

GO:0044238

GO:0046872

GO:0048471

GO:0070536

GO:0071108

GO:0098542

GO:0101005

GO:0140096

GO:0140374

HMNXSV003007163

ILMN_1750325

ILMN_1771642

PH_hs_0000562

TC09000725.hg

g5730107_3p_at

Participates

as a member of

USP20,USP33 [cytosol] (Homo sapiens)

Inferred To

Usp20 [cytosol] (Rattus norvegicus)

USP20 [cytosol] (Bos taurus)

USP20 [cytosol] (Canis familiaris)

USP20 [cytosol] (Danio rerio)

USP20 [cytosol] (Mus musculus)

USP20 [cytosol] (Sus scrofa)

USP20 [cytosol] (Xenopus tropicalis)

Usp20-33 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

XP_005251722.1, XP_011516464.1, NP_006667.3, XP_011516463.1, NP_001008563.2, NP_001103773.2

OpenTargets

ENSG00000136878

IntEnz

3.4.19.12

GeneCards

Q9Y2K6

HPA

ENSG00000136878-USP20

ZINC target

Q9Y2K6

Ensembl

ENST00000315480, ENSP00000361506, ENST00000372429, ENSP00000351122, ENSG00000136878, ENSP00000313811, ENST00000358355

PRO

Q9Y2K6

Pharos - Targets

Q9Y2K6

Orphanet

25024

PDB

6KCZ

HMDB Protein

HMDBP11586

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95714 HERC2	5	HERC2 [nucleoplasm] (R-HSA-4551680) p-T4827-HERC2 [nucleoplasm] (R-HSA-5682601) p-T4827,SUMO1-HERC2 [nucleoplasm] (R-HSA-5682615) HERC2 [cytosol] (R-HSA-975975) monoSUMO1-HERC2 [nucleoplasm] (R-HSA-4551758)	0.564	2
UniProt:Q99814 EPAS1 (HIF2A)	5	HN-EPAS1 [cytosol] (R-HSA-1234112) 2xHP-EPAS1 [nucleoplasm] (R-HSA-1234151) 2xHP-EPAS1 [cytosol] (R-HSA-1234149) EPAS1 [nucleoplasm] (R-HSA-452560) EPAS1 [cytosol] (R-HSA-1234119)	0.556	3
UniProt:P50553 ASCL1	1	ASCL1 [nucleoplasm] (R-HSA-212402)	0.556	3
UniProt:Q13352 ITGB3BP	2	ITGB3BP [cytosol] (R-HSA-3006405) ITGB3BP [nucleoplasm] (R-HSA-606325)	0.556	3
UniProt:Q96RU7 TRIB3	3	TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [cytosol] (R-HSA-162411) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.556	3
UniProt:O43597 SPRY2	8	p-S111,S120-SPRY2 [cytosol] (R-HSA-1295590) p-Y55-SPRY2 [cytosol] (R-HSA-182950) SPRY2 [plasma membrane] (R-HSA-182924) SPRY2 [cytosol] (R-HSA-182949) p-S112,S115-SPRY2 [cytosol] (R-HSA-1295619) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-934555) p-S112,S121-SPRY2 [plasma membrane] (R-HSA-934595) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-1295629)	0.556	3
UniProt:P13196 ALAS1	2	PXLP-ALAS1 [mitochondrial matrix] (R-HSA-1022086) ALAS1 [mitochondrial matrix] (R-HSA-189438)	0.556	3

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