Reactome | ALK fusion proteins [cytosol]

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ALK fusion proteins [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane [Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-9700179] Ligand-independent dimerization of ALK fusions - Homo sapiens [Reaction:R-HSA-9700179] Ligand-independent dimerization of ALK fusions - Homo sapiens
created	[InstanceEdit:9700089] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9700080
disease	[Disease:1500689] cancer
displayName	ALK fusion proteins [cytosol]
hasCandidate	[EntityWithAccessionedSequence:R-HSA-9700460] WDCP(1-680)-ALK(1061-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9710852] CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9710829] ATIC(1-229)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9710839] EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9711968] KLC1(1-420)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9711970] HIP1(1-1019)-ALK(1058-1620) [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9711952] HIP1(1-719)insL-ALK(1059-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9711972] HIP1(1-963)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9711979] TPR(2-629)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9701997] DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9711960] DCTN1(1-599)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9711954] SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9711976] PPFIBP1(1-232)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9711955] PPFIBP1(1-349)insK-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9711974] CARS1(2-606)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9713478] SEC31A(1-989)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9713480] VCL(1-811)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9713450] BIRC6(1-958)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9713456] EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9713477] PPM1B(2-282)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9713471] PRKAR1A(1-183)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9713458] GCC2(1-1204)-ALK(1059-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9713457] LMO7(1-1073)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9702002] RANBP2(1-867)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9702005] RRBP1(1-1253)insTPERALSSGLH-ALK(1106-1620) fusion [endoplasmic reticulum membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9713444] BCL11A(1-219)insDHPPA-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9730697] NPM1(1-117)-ALK(1068-1620) fusion [cytosol] - Homo sapiens
hasMember	[EntityWithAccessionedSequence:R-HSA-9710832] ATIC(1-230)-ALK(1059-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9710853] CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9711969] DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9699862] EML4(1-223)-ALK(1059-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9699813] EML4(1-223)insKMSTREKNSQV-ALK(1059-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9716112] EML4(1-569)-ALK(1078-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9699812] EML4(1-496)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9716119] EML4(1-780)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9713459] FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9711964] KIF5B(2-575)-ALK(1063-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9711966] MSN(2-448)-ALK(1064-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9699834] NPM1(1-117)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9700485] STRN(1-137)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9699874] TFG(1-138)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9699887] TFG(1-193)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9699806] TFG(1-240)-ALK(1058-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9710848] TPM3(2-258)insV-ALK(1059-1620) fusion [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9710851] TPM4(2-222)insV-ALK(1059-1620) fusion [cytosol] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9710779] Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis [LiteratureReference:9710719] A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma [LiteratureReference:9710741] ALK+, CD30-, CD20- large B-cell lymphoma containing anaplastic lymphoma kinase (ALK) fused to clathrin heavy chain gene (CLTC) [LiteratureReference:9710767] Inhibition of anaplastic lymphoma kinase (ALK) activity provides a therapeutic approach for CLTC-ALK-positive human diffuse large B cell lymphomas [LiteratureReference:9711768] Kinase fusions are frequent in Spitz tumours and spitzoid melanomas [LiteratureReference:9711812] Novel ALK fusion partners in lung cancer [LiteratureReference:9699710] Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer [LiteratureReference:9701376] Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer [LiteratureReference:9648139] Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer [LiteratureReference:9713378] Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer [LiteratureReference:9711805] A novel KIF5B-ALK variant in nonsmall cell lung cancer [LiteratureReference:9711848] Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphoma [LiteratureReference:9699651] Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5) [LiteratureReference:9699682] Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma [LiteratureReference:9711850] Identification of the transforming STRN-ALK fusion as a potential therapeutic target in the aggressive forms of thyroid cancer [LiteratureReference:9699785] TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations [LiteratureReference:9699672] Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity [LiteratureReference:9710718] A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation [LiteratureReference:9710811] TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors
maxDepth	2
modified	[InstanceEdit:9863938] Matthews, Lisa, 2024-03-06
name	ALK fusion proteins
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9700080

Referrals

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[Reaction:R-HSA-9700179] Ligand-independent dimerization of ALK fusions

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