Reactome | NPM1(1-117)-ALK(1058-1620) fusion [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9699999] NPM1(1-117)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9699999] NPM1(1-117)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens
created	[InstanceEdit:9699845] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12021285] Mondo:0018908 [DatabaseIdentifier:9699860] COSMIC:COSF198
dbId	9699834
disease	[Disease:6802338] lymphoma [Disease:1500689] cancer [Disease:2328081] non-Hodgkin lymphoma
displayName	NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
endCoordinate	117
hasModifiedResidue	[FragmentInsertionModification:9699804] Insertion of residues 1058 to 1620 at 118 from UniProt:Q9UM73 ALK
inDisease	true
literatureReference	[LiteratureReference:9699651] Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5) [LiteratureReference:9699682] Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
maxDepth	1
memberOf	[CandidateSet:R-HSA-9700080] ALK fusion proteins [cytosol] - Homo sapiens
name	NPM1(1-117)-ALK(1058-1620) fusion Nucleophosmin B23 NPM_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:P06748] UniProt:P06748 NPM1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9699834
startCoordinate	1

(hasMember)	[CandidateSet:R-HSA-9700080] ALK fusion proteins [cytosol]
(hasComponent)	[Complex:R-HSA-9699999] NPM1(1-117)-ALK(1058-1620) fusion dimer [cytosol]

Cite Us!