Reactome | EML4(1-223)insKMSTREKNSQV-ALK(1059-1620) fusion [cytosol]

Schema > EntityWithAccessionedSequence > Entries

EML4(1-223)insKMSTREKNSQV-ALK(1059-1620) fusion [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9699976] EML4(1-223)insKMSTREKNSQV -ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9699976] EML4(1-223)insKMSTREKNSQV -ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens
created	[InstanceEdit:9699845] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020794] Mondo:0005233 [DatabaseIdentifier:9713351] COSMIC:COSF474
dbId	9699813
disease	[Disease:1247848] non-small cell lung carcinoma
displayName	EML4(1-223)insKMSTREKNSQV-ALK(1059-1620) fusion [cytosol]
endCoordinate	223
hasModifiedResidue	[FragmentInsertionModification:9699847] Insertion of residues 1059 to 1620 at 224 from UniProt:Q9UM73 ALK [FragmentReplacedModification:9699846] Replacement of residues 223 to 223 by EKMSTREKNSQV
inDisease	true
literatureReference	[LiteratureReference:9699710] Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer [LiteratureReference:9701376] Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer
maxDepth	1
memberOf	[CandidateSet:R-HSA-9700080] ALK fusion proteins [cytosol] - Homo sapiens
modified	[InstanceEdit:9832525] Orlic-Milacic, Marija, 2023-04-02
name	EML4(1-223)insKMSTREKNSQV-ALK(1059-1620) fusion Echinoderm microtubule-associated protein-like 4 EMAL4_HUMAN variant 3b Exon 6 - Exon 20
referenceEntity	[ReferenceGeneProduct:uniprot:Q9HC35] UniProt:Q9HC35 EML4
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9699813
startCoordinate	1
updateTrackers	[UpdateTracker:9905394] Update Tracker - [EntityWithAccessionedSequence:9699813] EML4(1-223)insKMSTREKNSQV-ALK(1059-1620) fusion [cytosol] - v85:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9905394] Update Tracker - [EntityWithAccessionedSequence:9699813] EML4(1-223)insKMSTREKNSQV-ALK(1059-1620) fusion [cytosol] - v85:[modifyName]
(hasMember)	[CandidateSet:R-HSA-9700080] ALK fusion proteins [cytosol]
(hasComponent)	[Complex:R-HSA-9699976] EML4(1-223)insKMSTREKNSQV -ALK(1059-1620) fusion dimer [cytosol]

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