Reactome | PPM1B(2-282)-ALK(1058-1620) fusion [cytosol]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-HSA-9700080] ALK fusion proteins [cytosol] - Homo sapiens
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9713504] PPM1B(2-282)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9713504] PPM1B(2-282)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens
created	[InstanceEdit:9713473] Rothfels, Karen, 2021-01-26
crossReference	[DatabaseIdentifier:12020794] Mondo:0005233
dbId	9713477
disease	[Disease:1247848] non-small cell lung carcinoma
displayName	PPM1B(2-282)-ALK(1058-1620) fusion [cytosol]
endCoordinate	479
hasModifiedResidue	[FragmentInsertionModification:9713426] Insertion of residues 1058 to 1620 at 283 from UniProt:Q9UM73 ALK
inDisease	true
literatureReference	[LiteratureReference:9713415] Comprehensive Genomic Profiling Identifies a Subset of Crizotinib-Responsive ALK-Rearranged Non-Small Cell Lung Cancer Not Detected by Fluorescence In Situ Hybridization
maxDepth	1
name	PPM1B(2-282)-ALK(1058-1620) fusion Protein phosphatase 1B ecNumber3.1.3.16/ecNumber PPM1B_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:O75688] UniProt:O75688 PPM1B
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9713477
startCoordinate	2

(hasCandidate)	[CandidateSet:R-HSA-9700080] ALK fusion proteins [cytosol]
(hasComponent)	[Complex:R-HSA-9713504] PPM1B(2-282)-ALK(1058-1620) fusion dimer [cytosol]

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